ENA-VASP proteins (Ena-VASP-homology proteins)

enabled protein is expressed at high levels in axons of embryonic nervous system in Drosophila; GenBank U21123; enabled is the founding member of the ENA/VASP proteins; they are a conserved family of actin filament elongating factors made up of EVH1, EVH2 domains, and a proline-rich central region; they recruit profilin-actin complexes to sites of active actin remodelling

Also Known As:

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Krause, Matthias: 2 articles (01/2017 - 09/2014)
2.	Krause, M: 2 articles (01/2016 - 01/2008)
3.	Alqadri, N: 1 article (01/2017)
4.	Bennett, D: 1 article (01/2017)
5.	Bodo, Cristian: 1 article (01/2017)
6.	Dodgson, L: 1 article (01/2017)
7.	Fernandes, Cathy: 1 article (01/2017)
8.	Lyulcheva, E: 1 article (01/2017)
9.	Mason, D: 1 article (01/2017)
10.	Messina, G: 1 article (01/2017)

Related Diseases

1.	Cicatrix (Scar) 01/01/2016 - "Mechanistically, we show that Lamellipodin promotes invasive 3D cancer cell migration via both actin-elongating Ena/VASP proteins and the Scar/WAVE complex, which stimulates actin branching. " 01/01/2017 - "Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. " 01/01/2017 - "The Mig10/RIAM/Lpd (MRL) adapter protein Lpd regulates actin dynamics through interactions with Scar/WAVE and Ena/VASP proteins to promote the formation of cellular protrusions and to stimulate invasive migration. " 10/01/2014 - "Recent work reveals that many molecules important in vertebrate cell motility, including integrins, formins, Ena/VASP proteins and the SCAR/WAVE complex, have a conserved function in these innate immune cells. " 09/01/2014 - "Recently, advances have been made in our understanding of positive and negative ARP2/3 regulators (such as the SCAR/WAVE (SCAR/WASP family verprolin-homologous protein) complex and Arpin, respectively) and of proteins that control actin branch stability (such as glial maturation factor (GMF)) or actin filament elongation (such as ENA/VASP proteins) in lamellipodium dynamics and cell migration. "
2.	Neoplasms (Cancer) 01/01/2016 - "FAT2 and FAT3 are relatively less studied and are thought to participate in the development of human cancer through a pathway similar to that of the Ena/VASP proteins. " 01/01/2016 - "Mechanistically, we show that Lamellipodin promotes invasive 3D cancer cell migration via both actin-elongating Ena/VASP proteins and the Scar/WAVE complex, which stimulates actin branching. " 06/15/2009 - "Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance, endothelial barrier function, and cancer cell invasion and metastasis. " 01/01/2008 - "Growing evidence links Ena/VASP proteins to important human diseases, such as thrombosis, cancer, arteriosclerosis, cardiomyopathy and nephritis. "
3.	Thrombosis (Thrombus) 01/01/2008 - "Growing evidence links Ena/VASP proteins to important human diseases, such as thrombosis, cancer, arteriosclerosis, cardiomyopathy and nephritis. "
4.	Nephritis 01/01/2008 - "Growing evidence links Ena/VASP proteins to important human diseases, such as thrombosis, cancer, arteriosclerosis, cardiomyopathy and nephritis. "
5.	Neoplasm Metastasis (Metastasis) 06/15/2009 - "Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in several physiological processes such as morphogenesis, axon guidance, endothelial barrier function, and cancer cell invasion and metastasis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Profilins (Profilin)
3.	Glia Maturation Factor (GMF)
4.	Integrins
5.	Actins (F Actin)
6.	Formins