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tyrosyl- tetrahydroisoquinolinecarbonyl- psi(methylamino)phenylalanyl- phenylalanine

a delta-selective opioid peptide antagonist

Also Known As:

H-Tyr-Tic-psi(CH2NH)Phe-Phe-OH; TIPP(psi)

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - tyrosyl-tetrahydroisoquinolinecarbonyl-psi(methylamino)phenylalanyl-phenylalanine: 5

Experts

1.	Maslov, L N: 4 articles (01/2021 - 01/2003)
2.	Tsibulnikov, S Y: 2 articles (01/2021 - 01/2019)
3.	Khaliuli, I: 1 article (01/2021)
4.	Mukhomedzyanov, A V: 1 article (01/2021)
5.	Oeltgen, P R: 1 article (01/2021)
6.	Popov, S V: 1 article (01/2021)
7.	Prasad, N R: 1 article (01/2021)
8.	Khaliulin, I: 1 article (01/2019)
9.	Kolar, F: 1 article (01/2019)
10.	Lishmanov, Y B: 1 article (01/2019)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2003 - "Inhibition of delta-opioid receptors by intravenous administration of the selective delta-opioid antagonist TIPP (psi) in a dose of 0.5 mg/kg, intravenously (i.v.), completely abolished the antiarrhythmic effect of adaptation to hypoxia. " 01/01/2019 - "Pre-incubation of the cells with either the non-selective OR (opioid receptor) blocker naloxone (300 nM/l), the delta OR antagonist TIPP(psi) (30 nM/l), the selective delta(2) OR antagonist naltriben (1 nM/l) or the micro OR antagonist CTAP (100 nM/l) for 25 minutes before anoxia abolished the reduction of cell death and LDH release afforded by CNH. "
2.	Tics (Tic) 04/01/1996 - "In membranes of clone D2 cells the opioid peptide [D-Ala(2)]-leucine enkephalin (DADLE) produced a robust, concentration-dependent, stimulation of basal high-affinity GTPase activity; the prototypic opioid antagonist naloxone and the highly selective and potent delta opioid ligands H-Tyr-Tic-Phe-Phe-OH (TIPP) and H-Tyr-Tic[Ch2-NH]Phe-Phe-OH (TIPP[psi]) had little effect but N,N-diallyl-Tyr-Aib-Aib-Phe-Leu (ICI174864) caused a marked dose-dependent inhibition of this activity (Tic, 1,2,3,4-tetrahydroisoquinolin-2-yl-carbonyl]; Aib, alpha-aminobutyric acid). "
3.	Ischemia 10/01/2004 - "Perfusion with a solution containing the delta-opioid receptor agonist DPDPE or delta-antagonists naltrindole, TIPP[psi], and ICI 174,864 before modeling of global ischemia increased the severity of reperfusion-induced contractile dysfunction in the myocardium. "
4.	Infarction (Infarctions) 01/01/2021 - "receptor antagonist TIPP[psi] and the selective opioid µ receptor antagonist CTAP did not alter the infarct reducing effect of (-)-U-50,488 and ICI 199,441. "

Related Drugs and Biologics

1.	delta Opioid Receptors (delta Opioid Receptor)
2.	Narcotic Antagonists (Opioid Antagonists)
3.	Naloxone (Narcan)
4.	Opioid Analgesics (Opioids)
5.	D-Penicillamine (2,5)- Enkephalin
6.	GTP Phosphohydrolases (GTPases)
7.	Opioid Peptides (Opioid Peptide)
8.	Leucine-2-Alanine Enkephalin (Enkephalin, Leucine 2 Alanine)
9.	Solutions
10.	Opioid Receptors (Opioid Receptor)

Related Therapies and Procedures

1.	Intravenous Administration