thymidine kinase 1

08/01/2011 - "Tumor 3'-deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) uptake by PET correlates with thymidine kinase 1 expression: static and kinetic analysis of (18)F-FLT PET studies in lung tumors."
01/01/2003 - "We report the first mutational study of thymidine kinase 1 (TK1) performed in human solid tumors. "
10/01/2015 - "Thymidine kinase 1 (TK1) activity has been shown to be increased in various cancer types and proposed as a prognostic parameter. "
03/01/2015 - "Thymidine kinase 1 (TK1) is an important cancer biomarker whose serum levels are elevated in early cancer development. "
10/01/2014 - "To determine the application of serum thymidine kinase 1 (STK1) in general health screening for early detection of premalignant/early malignant tumors. "

02/01/2013 - "Comparison of diagnostic and prognostic performance of two assays measuring thymidine kinase 1 activity in serum of breast cancer patients."
01/01/2012 - "Thymidine kinase 1 upregulation is an early event in breast tumor formation."
01/01/2010 - "Serum thymidine kinase 1 activity in breast cancer."
01/01/2009 - "Elevated levels of thymidine kinase 1 peptide in serum from patients with breast cancer."
11/01/2006 - "The prognostic value of the concentration of serum thymidine kinase 1 (S-TK1) with regard to recurrence in low risk breast cancer patients, 3 months after surgery was evaluated. "

01/01/2015 - "The tomato thymidine kinase 1 (ToTK1) is a dNK that has been selected for its in vitro kinetic properties and then successfully been tested in vivo for the treatment of malignant glioma. "
11/01/2013 - "N5-2OH is an excellent substrate of thymidine kinase 1 and its favorable biodistribution profile in rodents led to successful preclinical NCT of rats bearing intracerebral RG2 glioma. "
06/01/2010 - "Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy."
12/01/2015 - "In this report we describe studies with N5-2OH, a carboranyl thymidine analog (CTA), which is a substrate for thymidine kinase 1 (TK1), using the F98 rat glioma model. "
01/01/2014 - "A promising suicide gene therapy system to treat gliomas has been reported: the thymidine kinase 1 from tomato (toTK1) combined with the nucleoside analog pro-drug zidovudine (azidothymidine, AZT), which is known to penetrate the blood-brain barrier. "

09/01/2008 - "This study evaluated the clinical utility of serum thymidine kinase 1 (STK1) in following the progression of pre-malignancies and malignancies and in monitoring the response of common carcinomas to therapy within a routine clinical setting. "
07/01/2010 - "Serological thymidine kinase 1 is a prognostic factor in oesophageal, cardial and lung carcinomas."
06/01/2010 - "The activity of the proliferation related enzyme thymidine kinase 1 (TK1) was reported to be 3-fold higher in extracts from normal kidney tissue as compare to renal carcinoma extracts [3]. "
04/01/2010 - "To investigate transient increases of thymidine kinase 1 in serum (STK1) after surgery of patients with carcinoma. "
04/01/2010 - "Transient increase in serum thymidine kinase 1 within one week after surgery of patients with carcinoma."

10/01/2012 - "A sensitive and kinetically defined radiochemical assay for canine and human serum thymidine kinase 1 (TK1) to monitor canine malignant lymphoma."
02/01/2009 - "Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay."
10/01/2005 - "Activity of thymidine kinase 1 in serum (STK) is a useful marker for leukaemia and lymphoma, but not for solid tumors. "
02/01/2006 - "The aim of this study was to evaluate an enzyme-linked immunosorbent assay (ELISA), for determination of serum thymidine kinase 1 (sTK1) activity in dogs with malignant lymphoma (ML) and compare it with a thymidine kinase (TK) radioenzymatic assay (TK-REA). "