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1- (5- (2- thenyloxy)- 1H- indol- 3- yl)propan- 2- amine

a 5-HT(2B) agonist

Also Known As:

BW 72386; BW 723C86; BW-72386; BW-723C86; BW723C86

Networked: 13 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine: 13
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine: 13
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 1-(5-(2-thenyloxy)-1H-indol-3-yl)propan-2-amine: 13

Experts

1.	Huo, Fu-Quan: 1 article (01/2020)
2.	Jia, Hong: 1 article (01/2020)
3.	Liu, Hua: 1 article (01/2020)
4.	Tang, Jing-Shi: 1 article (01/2020)
5.	Wang, Yu-Ying: 1 article (01/2020)
6.	Xu, Wen-Jin: 1 article (01/2020)
7.	Zhao, Yan: 1 article (01/2020)
8.	Bo, Jinhua: 1 article (01/2019)
9.	Gu, Xiaoping: 1 article (01/2019)
10.	Hou, Bailing: 1 article (01/2019)

Related Diseases

1.	Hyperphagia (Overeating) 02/01/1997 - "BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats." 04/12/2016 - "BW723C86, a serotonin receptor 2B agonist, has been investigated as a potential therapeutic for various conditions such as anxiety, hyperphagia and hypertension. "
2.	Hypertension (High Blood Pressure) 04/12/2016 - "BW723C86, a serotonin receptor 2B agonist, has been investigated as a potential therapeutic for various conditions such as anxiety, hyperphagia and hypertension. "
3.	Hyperalgesia 06/01/2012 - "A single application of BW723C86 on the sciatic nerve concomitantly to CCI dose-dependently prevented mechanical allodynia and significantly reduced cold allodynia 17 days after CCI. " 06/01/2012 - "Intrathecal administration of 5-HT(2B) receptor agonist BW723C86 significantly attenuated established mechanical and cold allodynia; this effect was prevented by co-injection of RS127445, a selective 5-HT(2B) receptor antagonist. " 01/01/2019 - "RVM microinjection of the CCK2 receptor agonist CCK-8 and intrathecal injection of the 5-HT2B receptor agonist BW723C86 both produced hyperalgesia in female rats after plantar incision, whereas the CCK2 receptor antagonist YM022, the 5-HT2B receptor antagonist RS127445, and the PKCγ inhibitor C37H65N9O13 decreased the rats' sensitivity to the same stimulus. " 01/01/2020 - "Microinjection of preferential or selective 5-HT2A/C, 5-HT2B and 5-HT2C receptor agonists, (±)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), α-methyl-5-(2-thienylmethoxy)-1H-Indole-3-ethanamine hydrochloride (BW723C86) and 1-(3-Chlorophenyl)-piperazine hydrochloride (m-CPP) into the VLO significantly depressed allodynia induced by SNI, and the inhibitory effect of DOI was blocked or attenuated by selective 5-HT2A/C receptor antagonists ketanserin (+)-tartrate salt (ketanserin) and 5-HT2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenylethyl)]-4-piperidinemethanol (M100907); the effects of BW723C86 and m-CPP were antagonized by 5-HT2B receptor antagonists N-(1-Methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea (SB204741) and 5-HT2C receptor antagonist RS102221 hydrochloride hydrate (RS-102221), respectively. "
4.	Migraine Disorders (Migraine) 03/15/2015 - "BF-1 was tested as potential migraine prophylactic drug by blocking meta-chlorophenylpiperazine, (mCPP) or BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) induced neurogenic dural plasma protein extravasation in a guinea pig model that may resemble a migraine attack. " 02/01/2001 - "Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC)."
5.	Hyperpigmentation 04/12/2016 - "These results suggest that the serotonin agonist BW723C86 could be a potential therapeutic agent for skin hyperpigmentation disorders."

Related Drugs and Biologics

1.	Serotonin Receptors
2.	5-HT2B Serotonin Receptor
3.	1-(3-chlorophenyl)piperazine
4.	Serotonin (5 Hydroxytryptamine)
5.	Salts
6.	2- amino- 4- (4- fluoronaphth- 1- yl)- 6- isopropylpyrimidine
7.	Desoxycorticosterone Acetate (DOCA)
8.	5-HT2C Serotonin Receptor
9.	5-HT2A Serotonin Receptor (5 HT2A Receptor)
10.	Cholecystokinin B Receptor

Related Therapies and Procedures

1.	Spinal Injections