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CGP 47969A

inhibits biosynthesis of IL-1, IL-6 and other cytokines

Also Known As:

1-(4-(chloroacetyl-(2-isopropoxyethyl)amino)benzoyl)-4-(2-(4-chlorophenyl)ethyl)piperazine hydrochloride; CGP-47969A

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - CGP 47969A: 3

Related Diseases

1.	Colitis 09/01/1995 - "The aim of the present study was to determine the effects of a novel cytokine antagonist (CGP 47969A) in a rabbit model of acute colitis. " 09/01/1995 - "Animals were pretreated intrarectally with CGP 47969A (30, 10, or 3 mg/kg), hydrocortisone (0.8 mg/kg), or vehicle (4 mL saline) 2 hours before the induction of colitis and twice daily thereafter until death 48 hours after the induction of colitis. " 09/01/1995 - "Anti-inflammatory effects of CGP 47969A, a novel inhibitor of proinflammatory cytokine synthesis, in rabbit immune colitis." 09/01/1995 - "Administration of CGP 47969A reduces inflammation and tissue damage in rabbit immune complex colitis through mechanisms involving the inhibition of mucosal proinflammatory cytokines."
2.	Arthritis (Polyarthritis) 11/01/1994 - "At a dose of 120 mg/kg, CGP 47969A totally prevented the occurrence of arthritis (ED50 between 1 and 5 mg/kg). " 11/01/1994 - "CGP 47969A dose dependently reduced the incidence of arthritis from 93% in the positive control group to 60, 40, 30 and 10% at doses of 1, 5, 25 and 60 mg/kg/day, respectively. " 11/01/1994 - "The ability of CGP 47969A to inhibit cytokine and NO production may explain its efficacy in animal models of arthritis."
3.	Necrosis 09/01/1995 - "Compared with vehicle, CGP 47969A (10 mg/kg) significantly reduced the acute inflammatory index by 58%, edema by 67%, necrosis by 99%, and myeloperoxidase activity by 49% (all P < 0.02) with efficacy similar to that of steroids. "
4.	Inflammation (Inflammations) 09/01/1995 - "Administration of CGP 47969A reduces inflammation and tissue damage in rabbit immune complex colitis through mechanisms involving the inhibition of mucosal proinflammatory cytokines."
5.	Edema (Dropsy) 09/01/1995 - "Compared with vehicle, CGP 47969A (10 mg/kg) significantly reduced the acute inflammatory index by 58%, edema by 67%, necrosis by 99%, and myeloperoxidase activity by 49% (all P < 0.02) with efficacy similar to that of steroids. "

Related Drugs and Biologics

1.	Cytokines
2.	Steroids
3.	Prednisolone (Predate)
4.	Peroxidase (Myeloperoxidase)
5.	Hydrocortisone (Cortisol)
6.	Antigen-Antibody Complex (Immune Complex)