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CGP 47969A
inhibits biosynthesis of IL-1, IL-6 and other cytokines
Also Known As:
1-(4-(chloroacetyl-(2-isopropoxyethyl)amino)benzoyl)-4-(2-(4-chlorophenyl)ethyl)piperazine hydrochloride; CGP-47969A
Networked:
3
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Piperazines: 26
CGP 47969A: 3
Related Diseases
1.
Colitis
09/01/1995 - "
The aim of the present study was to determine the effects of a novel cytokine antagonist (CGP 47969A) in a rabbit model of acute colitis.
"
09/01/1995 - "
Animals were pretreated intrarectally with CGP 47969A (30, 10, or 3 mg/kg), hydrocortisone (0.8 mg/kg), or vehicle (4 mL saline) 2 hours before the induction of colitis and twice daily thereafter until death 48 hours after the induction of colitis.
"
09/01/1995 - "
Anti-inflammatory effects of CGP 47969A, a novel inhibitor of proinflammatory cytokine synthesis, in rabbit immune colitis.
"
09/01/1995 - "
Administration of CGP 47969A reduces inflammation and tissue damage in rabbit immune complex colitis through mechanisms involving the inhibition of mucosal proinflammatory cytokines.
"
2.
Arthritis (Polyarthritis)
11/01/1994 - "
At a dose of 120 mg/kg, CGP 47969A totally prevented the occurrence of arthritis (ED50 between 1 and 5 mg/kg).
"
11/01/1994 - "
CGP 47969A dose dependently reduced the incidence of arthritis from 93% in the positive control group to 60, 40, 30 and 10% at doses of 1, 5, 25 and 60 mg/kg/day, respectively.
"
11/01/1994 - "
The ability of CGP 47969A to inhibit cytokine and NO production may explain its efficacy in animal models of arthritis.
"
3.
Necrosis
09/01/1995 - "
Compared with vehicle, CGP 47969A (10 mg/kg) significantly reduced the acute inflammatory index by 58%, edema by 67%, necrosis by 99%, and myeloperoxidase activity by 49% (all P < 0.02) with efficacy similar to that of steroids.
"
4.
Inflammation (Inflammations)
09/01/1995 - "
Administration of CGP 47969A reduces inflammation and tissue damage in rabbit immune complex colitis through mechanisms involving the inhibition of mucosal proinflammatory cytokines.
"
5.
Edema (Dropsy)
09/01/1995 - "
Compared with vehicle, CGP 47969A (10 mg/kg) significantly reduced the acute inflammatory index by 58%, edema by 67%, necrosis by 99%, and myeloperoxidase activity by 49% (all P < 0.02) with efficacy similar to that of steroids.
"
Related Drugs and Biologics
1.
Cytokines
2.
Steroids
3.
Prednisolone (Predate)
4.
Peroxidase (Myeloperoxidase)
5.
Hydrocortisone (Cortisol)
6.
Antigen-Antibody Complex (Immune Complex)