antineoplaston AS 2-1

a mixture of sodium salts of phenylacetic acid and phenylacetylglutamine in the ratio 4:1

Also Known As:

AS2-1 antineoplaston; NSC 620261; NSC-620261; antineoplaston AS2-1; antineoplaston AS21

Networked: 12 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Pharmaceutical Preparations
- Drug Combinations: 5337
  - antineoplaston AS 2-1: 12
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylacetates: 3
      - antineoplaston AS 2-1: 12

Experts

1.	Matono, Keiko: 2 articles (01/2014 - 03/2005)
2.	Ogata, Yutaka: 2 articles (01/2014 - 03/2005)
3.	Shirouzu, Kazuo: 2 articles (01/2014 - 03/2005)
4.	Tsuda, Hideaki: 2 articles (01/2014 - 03/2005)
5.	Akagi, Yoshito: 1 article (01/2014)
6.	Ushijima, Masataka: 1 article (01/2014)
7.	Araki, Yasumi: 1 article (03/2005)

Related Diseases

1.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/01/1986 - "The patients' diagnoses included: lung cancer, stage III, 4 cases; colorectal, stage IV, 3; breast, stage IV, 2; breast in remission, 1; glioblastoma, 3; head and neck, stage IV, 3; uterine cervix, stage IA, 1; chronic myelocytic leukaemia, 2; lymphocytic lymphoma, stage IV, 1; and leiomyosarcoma of the uterus, stage IVB, 1. Antineoplaston AS2-1 was administered every 6 h i.v. through subclavian vein catheter. "
2.	Lung Neoplasms (Lung Cancer) 01/01/1986 - "The patients' diagnoses included: lung cancer, stage III, 4 cases; colorectal, stage IV, 3; breast, stage IV, 2; breast in remission, 1; glioblastoma, 3; head and neck, stage IV, 3; uterine cervix, stage IA, 1; chronic myelocytic leukaemia, 2; lymphocytic lymphoma, stage IV, 1; and leiomyosarcoma of the uterus, stage IVB, 1. Antineoplaston AS2-1 was administered every 6 h i.v. through subclavian vein catheter. "
3.	Leiomyosarcoma 01/01/1986 - "The patients' diagnoses included: lung cancer, stage III, 4 cases; colorectal, stage IV, 3; breast, stage IV, 2; breast in remission, 1; glioblastoma, 3; head and neck, stage IV, 3; uterine cervix, stage IA, 1; chronic myelocytic leukaemia, 2; lymphocytic lymphoma, stage IV, 1; and leiomyosarcoma of the uterus, stage IVB, 1. Antineoplaston AS2-1 was administered every 6 h i.v. through subclavian vein catheter. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/1986 - "The patients' diagnoses included: lung cancer, stage III, 4 cases; colorectal, stage IV, 3; breast, stage IV, 2; breast in remission, 1; glioblastoma, 3; head and neck, stage IV, 3; uterine cervix, stage IA, 1; chronic myelocytic leukaemia, 2; lymphocytic lymphoma, stage IV, 1; and leiomyosarcoma of the uterus, stage IVB, 1. Antineoplaston AS2-1 was administered every 6 h i.v. through subclavian vein catheter. "
5.	Neoplasms (Cancer) 01/06/1995 - "The physiological consequence of this biochemical event could be critical to cancer cells and therefore might contribute to the mechanism of antineoplaston AS2-1 action." 01/01/1986 - "Toxicology studies on antineoplaston AS2-1 injections in cancer patients." 01/01/1996 - "Both agents inhibited cell proliferation and increased the number of cells in G0 and G1 phases and Antineoplaston AS2-1 induced apoptosis, we also describe our clinical experience of a hepatocellula carcinoma (HCC) patient whose tumor, after incomplete trancathere arterial embolization (TAE) for a 7cm 7cm HCC, has been stable for more than 15 months during which time he has been taking Antineoplaston AS2-1 continuously without any serious adverse effects." 01/01/2005 - "The influence of modified antineoplaston AS2-1 (with altered ratio of L-phenylalanine and L-glutamine derivatives, "Deglutam") on the activity of glutamine synthetase, glutaminase isoforms in the carcinosarcoma SM-1, tumor weight, per cent of the inhibition of tumor growth and blood impact index was investigated in rats with carcinosarcoma SM-1. "

Related Drugs and Biologics

1.	phenylacetic acid (phenylacetate)
2.	phenylacetylglutamine
3.	antineoplaston A10 (A 10)
4.	Cytostatic Agents
5.	Protein Isoforms (Isoforms)
6.	Sodium
7.	Salts
8.	Phenylalanine (L-Phenylalanine)
9.	Glutamate-Ammonia Ligase (Glutamine Synthetase)
10.	Glutamine (L-Glutamine)

Related Therapies and Procedures

1.	Catheters
2.	Injections
3.	Therapeutics