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DU 86

structure given in first source

Also Known As:

DU-86

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Duocarmycins: 63
        DU 86: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Duocarmycins: 63
        DU 86: 3

Experts

1.	Hanai, N: 1 article (10/2000)
2.	Nagamura, S: 1 article (10/2000)
3.	Ohta, S: 1 article (10/2000)
4.	Saito, H: 1 article (10/2000)
5.	Suzawa, T: 1 article (10/2000)
6.	Yamasaki, M: 1 article (10/2000)

Related Diseases

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/01/1995 - "Three duocarmycins, KW-2189, DU-86 and duocarmycin SA, were active against the cisplatin (CDDP)-resistant human non-small cell lung cancer cell lines PC-9/CDDP and PC-14/CDDP, and the multidrug-resistant human small cell lung cancer cell line H69/VP. "
2.	Neoplasms (Cancer) 10/03/2000 - "A model compound of anti-tumor agent, segment B of duocarmycin derivative DU-86, was conjugated to tumor-specific antibody via a cleavable linker consisting of poly(ethylene glycol) (PEG) and dipeptide, L-alanyl-L-valine (Ala-Val), to confirm the feasibility of the linker for application to immunoconjugate. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/1995 - "Three duocarmycins, KW-2189, DU-86 and duocarmycin SA, were active against the cisplatin (CDDP)-resistant human non-small cell lung cancer cell lines PC-9/CDDP and PC-14/CDDP, and the multidrug-resistant human small cell lung cancer cell line H69/VP. "
4.	Carcinoma (Carcinomatosis) 12/01/1994 - "Duocarmycin A (DUMA) and DU-86, a semisynthetic derivative of duocarmycins (DUMs) and a possible active form of KW-2189, both showed potent cell growth-inhibitory and cell-killing activities against human uterine cervix carcinoma HeLa S3 cells. "

Related Drugs and Biologics

1.	Duocarmycins
2.	KW 2189
3.	Ethylene Glycol (Monoethylene Glycol)
4.	Immunoconjugates (Immunoconjugate)
5.	Valine (L-Valine)
6.	Dipeptides
7.	Cisplatin (Platino)
8.	duocarmycin SA
9.	duocarmycin A