PEG-modified tumor necrosis factor-alpha

chemical modification of natural tumor necrosis factor-alpha with polyethylene glycol increases its anti-tumor potency

Also Known As:

MPEG-TNFalpha; polyethylene glycol-modified TNF-alpha

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Glycols: 38
    - Ethylene Glycols: 8
      - Polyethylene Glycols: 3865
        PEG-modified tumor necrosis factor-alpha: 1
Macromolecular Substances: 97
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - PEG-modified tumor necrosis factor-alpha: 1
Biomedical and Dental Materials
- Polymers: 13051
  - Polyethylene Glycols: 3865
    - PEG-modified tumor necrosis factor-alpha: 1
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomedical and Dental Materials
    - Polymers: 13051
      - Polyethylene Glycols: 3865
        PEG-modified tumor necrosis factor-alpha: 1
Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Tumor Necrosis Factor-alpha: 62515
      - PEG-modified tumor necrosis factor-alpha: 1
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Monokines: 214
        Tumor Necrosis Factor-alpha: 62515
        PEG-modified tumor necrosis factor-alpha: 1
      - Tumor Necrosis Factors: 152
        Tumor Necrosis Factor-alpha: 62515
        PEG-modified tumor necrosis factor-alpha: 1
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Monokines: 214
      - Tumor Necrosis Factor-alpha: 62515
        PEG-modified tumor necrosis factor-alpha: 1
    - Tumor Necrosis Factors: 152
      - Tumor Necrosis Factor-alpha: 62515
        PEG-modified tumor necrosis factor-alpha: 1

Related Diseases

1.	Neoplasms (Cancer) 12/01/1994 - "Complete regression of solid tumors was achieved by plural intravenous (i.v.) administrations of polyethylene glycol (PEG)-modified tumor necrosis factor-alpha (TNF-alpha), prepared by covalently modifying natural human TNF-alpha with N-succinimidyl succinate PEG. "

Related Drugs and Biologics

1.	Succinic Acid (Succinate)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Polyethylene Glycols (Polyethylene Glycol)