kalata B1

a 29-residue cyclotide which has a cystine knot structure and beta-sheet; causes uterine contraction; the principal active component from Oldenlandia affinis; amino acid sequence given in first source

Also Known As:

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Craik, David J: 3 articles (09/2014 - 01/2007)
2.	Göransson, Ulf: 2 articles (04/2016 - 09/2012)
3.	Banack, Sandra A: 1 article (01/2022)
4.	Cox, Paul Alan: 1 article (01/2022)
5.	Dunlop, Rachael A: 1 article (01/2022)
6.	Gerlach, Samantha L: 1 article (01/2022)
7.	Metcalf, James S: 1 article (01/2022)
8.	Gold-Binder, Markus: 1 article (04/2016)
9.	Gruber, Christian W: 1 article (04/2016)
10.	Gründemann, Carsten: 1 article (04/2016)

Related Diseases

1.	Multiple Sclerosis 09/01/2022 - "The cyclotide kalata B1 (kB1) has previously been discovered as immunosuppressive agent on T-lymphocytes, and a synthetic version of this peptide, [T20K]kB1 (T20K), has been effective in reducing clinical symptoms, such as inflammation and demyelination, in a mouse model of multiple sclerosis. "
2.	Inflammation (Inflammations) 09/01/2022 - "The cyclotide kalata B1 (kB1) has previously been discovered as immunosuppressive agent on T-lymphocytes, and a synthetic version of this peptide, [T20K]kB1 (T20K), has been effective in reducing clinical symptoms, such as inflammation and demyelination, in a mouse model of multiple sclerosis. "
3.	Demyelinating Diseases (Demyelinating Disease) 09/01/2022 - "The cyclotide kalata B1 (kB1) has previously been discovered as immunosuppressive agent on T-lymphocytes, and a synthetic version of this peptide, [T20K]kB1 (T20K), has been effective in reducing clinical symptoms, such as inflammation and demyelination, in a mouse model of multiple sclerosis. "
4.	Lymphoma (Lymphomas) 09/18/2012 - "The current study determined the possible DNA-damaging effects of three cyclotides, i.e., cycloviolacin O2, vaby D, and kalata B1, in human lymphoma cells by use of the alkaline version of the comet assay. "
5.	Neoplasms (Cancer) 09/01/2022 - "The nature inspired peptide [T20K]-kalata B1 induces anti-tumor effects in anaplastic large cell lymphoma." 09/05/2014 - "A novel set of analogues of kalata B1 (the prototypic cyclotide) and kalata B2 and cycloviolacin O2 were examined for their membrane-binding affinity and selectivity towards cancer cells. "

Related Drugs and Biologics

1.	Cyclotides
2.	Peptides (Polypeptides)
3.	Immunosuppressive Agents (Immunosuppressants)
4.	cycloviolacin O2
5.	DNA (Deoxyribonucleic Acid)
6.	vaby D
7.	Trypsin Inhibitors
8.	Protease Inhibitors (Protease Inhibitor)
9.	kalata B2
10.	trypsin inhibitor MCoTI-II