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A 62176

InChIKey: OLNJLTFSGFZCKE-JTQLQIEISA-N

Also Known As:

6-((3S)-3-Amino-1-pyrrolidinyl)-5-fluoro-3-oxo-3H-pyrido(3,2,1-kl)phenoxazine-2-carboxylic acid; A-62176

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - A 62176: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        A 62176: 3

Experts

1.	Choi, Yongmun: 1 article (12/2012)
2.	Jeon, Kyung-Hwa: 1 article (12/2012)
3.	Jun, Kyu-Yeon: 1 article (12/2012)
4.	Kim, Dae-Kee: 1 article (12/2012)
5.	Kim, Hye-Lin: 1 article (12/2012)
6.	Kwon, Youngjoo: 1 article (12/2012)
7.	Na, Younghwa: 1 article (12/2012)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 12/01/2012 - "A-62176 arrests the cell cycle in the G1 phase via the down-regulation of cyclin D1 and the up-regulation of p27(Kip1) in NCI-N87 gastric cancer cells. "
2.	Poisoning 09/20/1994 - "A-62176 antagonized the poisoning of topoisomerase II by VM-26 in vivo and in vitro, but had no effect on DNA breakage induced by camptothecin, a DNA topoisomerase I poison. "
3.	Neoplasms (Cancer) 06/11/1999 - "Quinobenzoxazine A-62176, developed from the antibacterial fluoroquinolones, is active in vitro and in vivo against murine and human tumors. "

Related Drugs and Biologics

1.	A-Form DNA (A-DNA)
2.	Fluoroquinolones
3.	Cyclin D1
4.	Teniposide (VM 26)
5.	Poisons
6.	Type I DNA Topoisomerases (Topoisomerase I)
7.	Type II DNA Topoisomerases (Topoisomerase II)
8.	DNA (Deoxyribonucleic Acid)
9.	Camptothecin