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sinitrodil
structure in first source
Also Known As:
3-(2-(nitrooxy)ethyl)-2H-1,3-benzoxazin-4(3H)-one; ITF 296; ITF-296
Networked:
6
relevant articles (
3
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Inorganic Chemicals: 9
Electrolytes: 16106
Ions: 7857
Anions: 3501
Nitrates: 6625
sinitrodil: 6
Nitrogen Compounds: 67
Nitric Acid: 155
Nitrates: 6625
sinitrodil: 6
Organic Chemicals: 133
Nitrates: 6625
sinitrodil: 6
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Oxazines: 9
Benzoxazines: 58
sinitrodil: 6
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzoxazines: 58
sinitrodil: 6
Related Diseases
1.
Stable Angina
08/01/1998 - "
The trends exhibited in this small preliminary study were consistently pharmacologically plausible and indicate that ITF-296 shows potential antiischaemic efficacy in patients with chronic stable angina.
"
08/01/1998 - "
Safety, tolerability, and antiischaemic efficacy of ITF-296, a nitric oxide donor, in patients with chronic stable angina.
"
08/01/1998 - "
A double-blind, placebo-controlled, parallel-group, dose-escalation study was performed to evaluate ITF-296, a new nitric oxide donor, in chronic stable angina.
"
2.
Coronary Stenosis (Coronary Artery Stenosis)
05/01/1995 - "
Therefore, both ITF 296 and ISDN improved BF to the deeper myocardial layers distal to a coronary artery stenosis.
"
05/01/1995 - "
We examined the effect of the novel nitrovasodilator ITF 296 and isosorbide dinitrate (ISDN) on myocardial blood flow (BF) distal to a coronary artery stenosis.
"
3.
Ischemia
01/01/1995 - "
Protective effects of ITF 296 in the isolated rabbit heart subjected to global ischemia.
"
01/01/1995 - "
Injection of ITF 296 (0.3-10 microM) into the perfusion system dose-dependently inhibited the increase in LVEDP that took place during ischemia and progressively improved the recovery of a regular rhythm in the isolated heart.
"
01/01/1995 - "
The anti-ischemic action of ITF 296 was evaluated in isovolumic, electrically driven rabbit heart preparations subjected to temporary ischemia and reperfusion.
"
01/01/1995 - "
Treatment with ITF 296 (1 and 10 microM) resulted in a dose-dependent increase in the rate of 6-keto-PGF1 alpha biosynthesis during both the ischemia and the reperfusion period (+157% over basal values).
"
4.
Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1995 - "
The protective effect of ITF 296 and ISDN against myocardial ischemia was also observed after oral administration, demonstrating good absorption and a limited first-pass metabolism of the two drugs.
"
01/01/1995 - "
Protective effect of the nitrate ester ITF 296 against methacholine-induced myocardial ischemia in the anesthetized rat.
"
01/01/1995 - "
The activity of ITF 296 against methacholine-induced myocardial ischemia was investigated in anesthetized rats in comparison with the organic nitrates nitroglycerin (NTG) and isosorbide dinitrate (ISDN), the K(+)-channel openers nicorandil and cromakalim, the Ca(2+)-channel blocker amlodipine, and the vasodilator dipyridamole.
"
5.
Myocardial Infarction
01/01/1995 - "
These results confirm that ITF 296 promotes an increase of flow to the border zone, thus possibly reducing the area of myocardial infarction.
"
Related Drugs and Biologics
1.
Nitric Oxide Donors
2.
Isosorbide Dinitrate (Isordil)
3.
Nicorandil (SG 75)
4.
Cromakalim (Levcromakalim)
5.
Amlodipine (Norvasc)
6.
Methacholine Chloride (Methacholine)
7.
6-Ketoprostaglandin F1 alpha (6 Ketoprostaglandin F1 alpha)
8.
Vasodilator Agents (Vasodilators)
9.
Nitrates
10.
Nitroglycerin (Dynamite)
Related Therapies and Procedures
1.
Oral Administration