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IDRA 21

modulates AMPA receptor desensitization ; structure given in first source

Also Known As:

7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-S,S-dioxide; IDRA-21

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazides: 1584
    - Benzothiadiazines: 3
      - IDRA 21: 4
  - Sulfones: 534
    - Sulfonamides: 2809
      - Benzothiadiazines: 3
        IDRA 21: 4
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiadiazines: 3
      - IDRA 21: 4

Experts

1.	Baraldi, Mario: 2 articles (06/2004 - 06/2004)
2.	Braghiroli, Daniela: 2 articles (06/2004 - 06/2004)
3.	Losi, Gabriele: 2 articles (06/2004 - 06/2004)
4.	Puia, Giulia: 2 articles (06/2004 - 06/2004)
5.	Buccafusco, Jerry J: 1 article (01/2004)
6.	Klinder, Klaus: 1 article (01/2004)
7.	Terry, Alvin V: 1 article (01/2004)
8.	Weiser, Thomas: 1 article (01/2004)
9.	Winter, Karin: 1 article (01/2004)

Related Diseases

1.	Cognitive Dysfunction 08/15/1995 - "7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys." 06/01/2004 - "IDRA-21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) reduces alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA) receptors desensitisation in vitro and restores learning and cognitive impairment in vivo. "
2.	Memory Disorders (Memory Loss) 01/01/2004 - "These findings support the use of AMPA modulators like IDRA 21 in the treatment of cognitive/memory disorders, including those associated with aging. "
3.	Ischemia 05/01/1998 - "However, AMPA receptor activation contributes to CA1 hippocampal neuron damage from global ischemia in rodents, raising the possibility that 7-chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21) or drugs with similar actions may worsen ischemic neuronal injury. " 05/01/1998 - "Here we demonstrate that glutamate plus IDRA 21 kills cultured rat hippocampal neurons by AMPA receptor activation, and, in vivo, 12 and 24 mg/kg of IDRA 21 given orally increases CA1 neuron loss produced by 10 minutes of global ischemia. "

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	Glutamic Acid (Glutamate)
3.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
4.	Acids
5.	aniracetam