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9-phenanthrol

an inhibitor of AMP-dependent protein kinase catalytic subunit; structure in first source

Also Known As:

9-hydroxyphenanthrene

Networked: 10 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        9-phenanthrol: 10
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - 9-phenanthrol: 10

Experts

1.	Naruse, Keiji: 2 articles (01/2015 - 01/2013)
2.	Piao, Hulin: 2 articles (01/2015 - 01/2013)
3.	Takahashi, Ken: 2 articles (01/2015 - 01/2013)
4.	Bölcskei, Kata: 1 article (01/2022)
5.	Csípő, Tamás: 1 article (01/2022)
6.	Czikora, Ágnes: 1 article (01/2022)
7.	Fülöp, Gábor Á: 1 article (01/2022)
8.	Gulyás, Hajnalka: 1 article (01/2022)
9.	Helyes, Zsuzsanna: 1 article (01/2022)
10.	Papp, Zoltán: 1 article (01/2022)

Related Diseases

1.	Infarction (Infarctions) 01/01/2015 - "Our previous study showed that 9-phenanthrol (9-Phe), a specific inhibitor of the TRPM4 channel, preserves cardiac contractile function and protects the heart from I/R injury-related infarction in the excised rat heart. "
2.	Hypoglycemia (Reactive Hypoglycemia) 01/01/2017 - "Our study shows that the major effect of 9-phenanthrol on the islets is a strong inhibition of insulin secretion, and we speculate that compounds related to 9-phenanthrol may be potentially useful in treating the pancreatogenous hyperinsulinemic hypoglycemia syndromes."
3.	Hypoxia (Hypoxemia) 04/01/2012 - "Transient receptor potential melastatin 4 inhibitor 9-phenanthrol abolishes arrhythmias induced by hypoxia and re-oxygenation in mouse ventricle." 04/01/2012 - "The aim of this study was to investigate the possible anti-arrhythmic effect of 9-phenanthrol, a TRPM4 inhibitor in a murine heart model of hypoxia and re-oxygenation-induced EADs. "
4.	Reperfusion Injury 01/01/2013 - "9-Phenanthrol, a TRPM4 inhibitor, protects isolated rat hearts from ischemia-reperfusion injury." 04/01/2014 - "Among promising potential applications, 9-phenanthrol exerts cardioprotective effects against ischaemia-reperfusion injuries and reduces ischaemic stroke injuries. "
5.	Brain Edema (Cerebral Edema) 01/01/2023 - "The TRPM4 channel inhibitor 9-phenanthrol alleviates cerebral edema after traumatic brain injury in rats." 10/01/2022 - "In vitro under circumstance of eliminating distractions from brain edema, SUR1-TRPM4 and NLRP3 inflammasome were also activated in BV2 cells subjected to lipopolysaccharides, or oxygen-glucose deprivation/reperfusion, which could be blocked by GLB or 9-phenanthrol, a TRPM4 inhibitor. "

Related Drugs and Biologics

1.	Anti-Arrhythmia Agents
2.	Inflammasomes
3.	KATP Channels
4.	Solutions
5.	Oxygen (Dioxygen)
6.	Lipopolysaccharides
7.	Glucose (Dextrose)
8.	Coal (Coals)
9.	5-hydroxydecanoic acid
10.	hydroxide ion