secreted phosphoprotein 24

a bone phosphoprotein; related in sequence to the cystatin family of thiol protease inhibitors; multiply phosphorylated at Ser residues in Ser-X-Glu/Ser(P) sequences; MW 24 kDa; amino acid sequence given in first source; GenBank U08018

Also Known As:

Networked: 8 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Murray, Samuel S: 5 articles (04/2017 - 11/2011)
2.	Wang, Jeffrey C: 5 articles (04/2017 - 11/2011)
3.	Lao, Lifeng: 4 articles (04/2017 - 02/2015)
4.	Tian, Haijun: 4 articles (04/2017 - 02/2015)
5.	Li, Yawei: 3 articles (11/2016 - 02/2015)
6.	Brochmann, Elsa J: 3 articles (10/2015 - 11/2011)
7.	Wasinger, Valerie C: 2 articles (11/2021 - 01/2020)
8.	Yau, Yunki Y: 2 articles (11/2021 - 01/2020)
9.	Shen, Jia: 2 articles (04/2017 - 11/2016)
10.	Daubs, Michael D: 2 articles (10/2015 - 02/2015)

Related Diseases

1.	Neuroinflammatory Diseases 02/01/2015 - "Similarly, in vivo, Spp24 reduced the expression of markers on neuroinflammation in animals treated with BMP-2 and also improved the function after BMP-2 administration. " 02/01/2015 - "In vitro, dorsal root ganglion cells were cultured in the presence of BMP-2 with and without Spp24 and calcitonin gene-related peptide and Substance P, markers of neuroinflammation, were measured by immunohistochemistry. "
2.	Neoplasms (Cancer) 01/01/2023 - "These results confirm the potential of Spp24 as a therapeutic agent for the treatment of OS and other skeletal tumors." 01/01/2023 - "Subcutaneous and intratibial tumor models in nude mice demonstrated that BMP-2 promoted OS growth in vivo, while Spp24 significantly inhibited tumor growth. " 01/01/2023 - "We found that BMP-2 increased the mobility and invasiveness of tumor cells in vitro whereas Spp24 inhibited both of these processes alone and in the presence of exogenous BMP-2. " 04/01/2017 - "Spp24 may have great potential for cancer treatment." 04/01/2017 - "TUNEL assay and immunochemical analysis further showed that spp24 could enhance tumor cell apoptosis and inhibit cell proliferation (p<0.01). "
3.	Osteosarcoma (Osteogenic Sarcoma) 01/01/2023 - "In this study, our aim was to investigate the effects of Secreted phosphoprotein 24 kD (Spp24) on the growth of osteosarcoma (OS) cells in the presence and absence of exogenous BMP-2 both in vitro and in vivo. " 01/01/2023 - "Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway."
4.	Prostatic Neoplasms (Prostate Cancer) 11/01/2016 - "In this study, we aimed to investigate the effects spp24 on the growth of prostate cancer caused by BMP2 in vitro and in vivo. " 11/01/2016 - "Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2." 11/01/2016 - "Spp24 can inhibit the growth of prostate cancer and its bone metastasis induced by BMP2; spp24 may have great potential to be a therapeutic agent in clinical situations."
5.	Hepatocellular Carcinoma (Hepatoma) 04/01/2017 - "In this study, we observed the inhibitory effect of spp24 on hepatocellular carcinoma in vivo. " 04/01/2017 - "Our data show that spp24 can inhibit the growth of hepatocellular carcinoma. " 04/01/2017 - "However, the effects of spp24 on hepatocellular carcinoma are not quite clear. " 04/01/2017 - "Secreted phosphoprotein 24kD (Spp24) inhibits growth of hepatocellular carcinoma in vivo."

Related Drugs and Biologics

1.	Phosphoproteins
2.	secreted phosphoprotein 24
3.	Bone Morphogenetic Protein 2
4.	Intercellular Signaling Peptides and Proteins (Growth Factors)
5.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
6.	Proliferating Cell Nuclear Antigen (PCNA)
7.	Calcitonin Gene-Related Peptide
8.	Biomarkers (Surrogate Marker)
9.	Substance P
10.	Carrier Proteins (Binding Protein)