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teludipine

GR66234A is the R-enantiomer; GR66235A is the L-enantiomer; hydrochloride is the active compound; structure given in first source

Also Known As:

GR66234A; GR66235A; teludipine hydrochloride

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Dihydropyridines: 214
      - teludipine: 1

Related Diseases

1.	Neoplasms (Cancer) 07/01/1994 - "The low calcium channel antagonistic activity of GR66234A suggests that this compound may be useful in combination with chemotherapy in MDR malignancies."
2.	Acute Erythroblastic Leukemia (Erythroleukemia) 07/01/1994 - "The daunorubicin resistance reversing activity of the enantiomers of teludipine was evaluated in two MDR cell lines: ARNII, an erythroleukemia cell line which expresses p-glycoprotein, and MCF 7/R, a breast cancer cell line with p-glycoprotein and high levels of glutathione S transferase (GST) and glutathione peroxidase (GSH Px). "
3.	Breast Neoplasms (Breast Cancer) 07/01/1994 - "The daunorubicin resistance reversing activity of the enantiomers of teludipine was evaluated in two MDR cell lines: ARNII, an erythroleukemia cell line which expresses p-glycoprotein, and MCF 7/R, a breast cancer cell line with p-glycoprotein and high levels of glutathione S transferase (GST) and glutathione peroxidase (GSH Px). "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Calcium Channels (Calcium Channel)
3.	Glutathione Transferase (Glutathione S-Transferase)
4.	Glutathione Peroxidase
5.	Daunorubicin (Cerubidine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)