ribonuclease HII

Degrades the ribonucleotide moiety on RNA-DNA hybrid molecules; participates in DNA replication; RNASEH2A, RNASEH2B, and RNASEH2C are subunits; RefSeq NM_006397 (human)

Also Known As:

RNASEH2A protein, human; RNASEH2B protein, human; RNASEH2C protein, human; RNAse HII, E coli; RNHIA protein, human; RNase HII; ribonuclease H2, human; ribonuclease H2, large subunit protein, human; ribonuclease HII, E coli; rnhB protein, E coli

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        Endoribonucleases: 176
        Ribonuclease H: 95
        ribonuclease HII: 5
      - Endonucleases: 1227
        Endoribonucleases: 176
        Ribonuclease H: 95
        ribonuclease HII: 5

Experts

1.	Basar Kılıc, Seyma: 1 article (01/2022)
2.	Borlu, Murat: 1 article (01/2022)
3.	Kianmehr, Leila: 1 article (01/2022)
4.	Mehmetbeyoglu, Ecmel: 1 article (01/2022)
5.	Rajabi-Maham, Hassan: 1 article (01/2022)
6.	Rassoulzadegan, Minoo: 1 article (01/2022)
7.	Taheri, Serpil: 1 article (01/2022)
8.	Yilmaz, Zeynep: 1 article (01/2022)
9.	Li, Jishan: 1 article (11/2015)
10.	Li, Yinhui: 1 article (11/2015)

Related Diseases

1.	Genomic Instability 01/01/2015 - "The aim of the present study was set to investigate the role of rnhB, presumably encoding RNase HII, in maintaining genome stability in the M. " 01/01/2015 - "Both, RNase HII substrates and RNase HII deficiency have been associated with genome instability in several organisms, and genome instability is a major force leading to the acquisition of drug resistance in bacteria. " 01/01/2015 - "The deletion of rnhB in Mycobacterium smegmatis does not affect the level of RNase HII substrates or influence genome stability." 01/01/2022 - "Since the genome is actively transcribed, cellular RNase-HII is essential for removing RNA from the DNA-RNA hybrid in controls of genome stability and epigenome shaping and can be used as a causal prognostic marker in patients with psoriasis." 03/01/2014 - "Pol I's strand displacement and FLAP-exo/endonuclease activities can be facilitated by alternate enzymes, while the DNA polymerization step can be assumed by high-fidelity pol III. We conclude that RNase HII and pol I normally act to minimize the genomic instability that is generated through errant ribonucleotide incorporation, but that the "nick-translation" activities encoded by the single pol I polypeptide can be undertaken by a variety of back-up enzymes. "
2.	Polymyositis 08/15/1997 - "Statistical models, hidden Markov models (HMMs), were created for the RNase HII, III, II and PH and D families as well as a double-stranded RNA binding domain present in RNase III. Results suggest that the RNase D family, which includes Werner syndrome protein and the 100 kDa antigenic component of the human polymyositis scleroderma (PMSCL) autoantigen, is a 3'-->5' exoribonuclease structurally and functionally related to the 3'-->5' exodeoxyribonuclease domain of DNA polymerases. "
3.	Werner Syndrome (Werner's Syndrome) 08/15/1997 - "Statistical models, hidden Markov models (HMMs), were created for the RNase HII, III, II and PH and D families as well as a double-stranded RNA binding domain present in RNase III. Results suggest that the RNase D family, which includes Werner syndrome protein and the 100 kDa antigenic component of the human polymyositis scleroderma (PMSCL) autoantigen, is a 3'-->5' exoribonuclease structurally and functionally related to the 3'-->5' exodeoxyribonuclease domain of DNA polymerases. "
4.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2022 - "Decrease in RNase HII and Accumulation of lncRNAs/DNA Hybrids: A Causal Implication in Psoriasis?" 01/01/2022 - "Since the genome is actively transcribed, cellular RNase-HII is essential for removing RNA from the DNA-RNA hybrid in controls of genome stability and epigenome shaping and can be used as a causal prognostic marker in patients with psoriasis."
5.	Pancreatic Neoplasms (Pancreatic Cancer) 11/07/2015 - "Coupled with RNase HII enzyme assisted amplification, this approach could realize T2DM-related SNP assay and be applied in crude extracts of carcinoma pancreatic β-cell lines. "

Related Drugs and Biologics

1.	Enzymes
2.	DNA (Deoxyribonucleic Acid)
3.	Complex Mixtures
4.	Ribonuclease III (RNase III)
5.	RNA (Ribonucleic Acid)
6.	Ribonucleotides
7.	Proteins (Proteins, Gene)
8.	Peptides (Polypeptides)
9.	Exoribonucleases
10.	Endonucleases