HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
SPM VIII
a spicamycin derivative; structure given in first source
Also Known As:
SPM-VIII; L-glycero-beta-L-manno-Heptopyranosylamine, 4-deoxy-4-((((1-oxododecyl)amino)acetyl)amino)-N-1H-purin-6-yl-
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Purine Nucleosides: 360
SPM VIII: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Purine Nucleosides: 360
SPM VIII: 4
Related Diseases
1.
Neoplasms (Cancer)
11/01/1994 - "
Although other pharmacological studies are in progress, these results suggest that SPM VIII might be a novel antitumor compound effective for human cancers including cancer of the digestive organs.
"
11/01/1994 - "
Comparative studies of SPM VIII given i.v. at 6 mg/kg/day daily for 5 days and MMC given i.v. at 6.7 mg/kg on day 1 revealed that the antitumor spectrum of SPM VIII showed a different pattern from that of MMC and that SPM VIII caused tumor mass reductions in more tumors than did MMC in colon cancers (4/12 versus 1/11).
"
09/01/1993 - "
SPM VIII showed the most activity against SC-9 in the human tumor xenograft model with the highest therapeutic index among SPMs.
"
11/01/1994 - "
The antitumor activity of spicamycin analogue SPM VIII against human stomach, breast, lung, colon and esophageal cancers was compared to that of mitomycin C (MMC) in the human tumor-nude mice xenograft model.
"
11/01/1994 - "
Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts.
"
2.
Colonic Neoplasms (Colon Cancer)
11/01/1994 - "
Comparative studies of SPM VIII given i.v. at 6 mg/kg/day daily for 5 days and MMC given i.v. at 6.7 mg/kg on day 1 revealed that the antitumor spectrum of SPM VIII showed a different pattern from that of MMC and that SPM VIII caused tumor mass reductions in more tumors than did MMC in colon cancers (4/12 versus 1/11).
"
12/01/1995 - "
The antitumor activity was greatly influenced by modification of the fatty acid moieties to tetradecadienoyl or dodecadienoyl analogues exhibiting better antitumor activity against COL-1 human colon cancer xenograft than SPM VIII.
"
11/01/1994 - "
In addition to this study, a comparative study of SPM VIII given i.v. at 12 mg/kg/day 8 times at 3- or 4-day intervals and 5'-deoxy-5-fluorouridine (5'-DFUR) given po at 185 mg/kg/day 5 days per week for 4 weeks showed that SPM VIII had the highest effect on SC-9 human stomach cancer and COL-1 human colon cancer among the 3 compounds, resulting in a significant reduction of tumor mass.
"
3.
Stomach Neoplasms (Stomach Cancer)
11/01/1994 - "
In addition to this study, a comparative study of SPM VIII given i.v. at 12 mg/kg/day 8 times at 3- or 4-day intervals and 5'-deoxy-5-fluorouridine (5'-DFUR) given po at 185 mg/kg/day 5 days per week for 4 weeks showed that SPM VIII had the highest effect on SC-9 human stomach cancer and COL-1 human colon cancer among the 3 compounds, resulting in a significant reduction of tumor mass.
"
4.
Leukemia
09/01/1993 - "
The cytotoxic activities of SPMs depended on the chain length of the fatty acid moiety, with dodecanoyl, tetradecanoyl, hexadecanoyl and icosanoyl analogues (SPM VIII, SPM X, SPM XII and SPM XVI) exhibiting the most potent cytotoxic activity against P388 murine leukemia cells.
"
06/01/1995 - "
The L-threonine analog and the glycylglycine analog of SPM VIII showed much higher cytotoxicity to P388 murine leukemia cells (IC50 5.8 nM and 0.11 nM, respectively) than SPM VIII (IC50 25nM).
"
5.
Esophageal Neoplasms (Esophageal Cancer)
11/01/1994 - "
The antitumor activity of spicamycin analogue SPM VIII against human stomach, breast, lung, colon and esophageal cancers was compared to that of mitomycin C (MMC) in the human tumor-nude mice xenograft model.
"
Related Drugs and Biologics
1.
N- (6- phenylhexyl)- 5- chloro- 1- naphthalenesulfonamide
2.
doxifluridine
3.
Fatty Acids (Saturated Fatty Acids)
4.
Mitomycin (Mitomycin-C)
5.
Threonine (L-Threonine)
6.
Nucleosides
7.
Glycylglycine (Diglycine)
8.
Anti-Bacterial Agents (Antibiotics)
9.
septacidin