conduritol B

RN given for ((1alpha,2beta,3alpha,4beta)-(+-))-isomer; structure in first source

Also Known As:

5-cyclohexene-1,2,3,4-tetrol; conduritol A; conduritol B, (1R-(1alpha,2alpha,3beta,4alpha))-isomer; conduritol B, (1alpha,2alpha,3alpha,4beta)-isomer; conduritol B, (1alpha,2beta,3beta,4alpha)-isomer; conduritol C

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Andresen, Thomas L: 1 article (10/2004)
2.	Madsen, Robert: 1 article (10/2004)
3.	Skytte, Dorthe M: 1 article (10/2004)

Related Diseases

Colonic Neoplasms (Colon Cancer)

10/21/2004 - "A divergent strategy is described for synthesis of the novel phosphatidylinositols 1-3. The synthetic approach commences from benzyl-protected methyl 6-iodo-6-deoxy-alpha-D-glucopyranoside, which undergoes zinc-mediated reductive fragmentation followed by vinyl Grignard addition and ring-closing metathesis to afford the key conduritol B intermediate 7. This can trifurcate to form three different benzyl-protected myo-inositol headgroups 4-6, which after phosphorylation and attachment of the glycerolipid part give phosphatidylinositols 1-3. Preliminary biological testing against human colon adenocarcinoma cells reveals that analogues 1-3 are significant anti-tumour agents."

Related Drugs and Biologics

1.	Zinc
2.	Phosphatidylinositols (Phosphatidylinositol)
3.	Inositol (Myoinositol)