MEN 10627

a polycyclic peptide; a tachykinin NK2 receptor antagonist; structure given in first source

Also Known As:

MEN 10,627; MEN-10627; cyclo(Met-Asp-Trp-Phe-Dap-Leu)cyclo(2beta-5beta); cyclo(methionyl-aspartyl-tryptophyl-phenylalanyl-diaminopropanoyl-leucyl)cyclo(2beta-5beta)

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - MEN 10627: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - MEN 10627: 2

Related Diseases

1.	Cough 10/01/1996 - "Indeed, a lot of studies have shown that tachykinin NK2 receptor antagonists (SR 48968, MEN 10627) are able to inhibit cough induced by citric acid, capsaicin or allergen challenge in the unanesthetized guinea-pig or mechanical stimulation of the trachea in the cat. "
2.	Ulcer 10/01/1997 - "The anti-secretory and anti-ulcer effects of Ala5NKA(4-10) were antagonized by pretreatment with the tachykinin NK2 receptor antagonist MEN 10,627 at a dose (250 micrograms/kg s.c.) which did not affect gastric secretion and ulcers. "

Related Drugs and Biologics

1.	Tachykinins
2.	Citric Acid (Citrate)
3.	Capsaicin (Zostrix)
4.	Allergens
5.	SR 48968 (saredutant)