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8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate

(R)-isomer is known to be an active cGMP-dependent protein kinase antagonist

Also Known As:

Rp-8-pCPT-cGMP(S); Rp-8-pCPT-cGMPS

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleotides: 140
        Guanine Nucleotides: 675
        Cyclic GMP: 803
        8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate: 5
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thionucleotides
    - 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate: 5

Experts

1.	Liu, Su: 2 articles (09/2014 - 10/2012)
2.	Chen, Li-ping: 1 article (09/2014)
3.	Liu, Gong-jian: 1 article (09/2014)
4.	Liu, Yue-peng: 1 article (09/2014)
5.	Zhang, Mao-yin: 1 article (09/2014)
6.	Huang, Zhi-Jiang: 1 article (10/2012)
7.	Li, Hao-Chuan: 1 article (10/2012)
8.	Song, Xue-Jun: 1 article (10/2012)
9.	Hervera, Arnau: 1 article (09/2010)
10.	Leánez, Sergi: 1 article (09/2010)

Related Diseases

1.	Hyperalgesia 09/01/2014 - "Meanwhile, in vivo intrathecal delivery of the Rp-8-pCPT-cGMPS significantly prevented and suppressed TCI-induced hyperalgesia and allodynia. " 10/25/2012 - "In vivo delivery of Rp-8-pCPT-cGMPS into the compressed ganglion within the intervertebral foramen suppresses CCD-induced thermal hyperalgesia. "
2.	Ganglion Cysts (Ganglion) 10/25/2012 - "In vivo delivery of Rp-8-pCPT-cGMPS into the compressed ganglion within the intervertebral foramen suppresses CCD-induced thermal hyperalgesia. "
3.	Neuralgia (Stump Neuralgia) 09/01/2010 - "The subplantar administration of NANT, l-NIL, ODQ, or Rp-8-pCPT-cGMPs dose-dependently inhibited neuropathic pain and enhanced the local effects of DPDPE or JWH-015. "
4.	Hypertrophy 10/01/2009 - "A PKG-1 antagonist, Rp-8-pCPT-cGMPS, blocked both Cu- and VEGFR-2 gene silencing-induced regression of cardiomyocyte hypertrophy. "
5.	Hypersensitivity (Allergy) 03/01/2009 - "Since the selective inhibitor of NO-sensitive guanylyl cyclase 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and the guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor Rp-8-pCPT-cGMPS intrathecally exerted dose-dependent analgesic effects on thermal and mechanical hypersensitivity, spinally released NO most likely stimulates the NO-cGMP-PKG pathway. "

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