N(6)-(1-iminoethyl)lysine

a selective inhibitor of inducible nitric oxide synthase; structure given in first source

Also Known As:

L-N6-(1-iminoethyl)Lys; L-N6-(1-iminoethyl)lysine; L-NIL cpd; L-iminoethyl-L-lysine; iNOS inhibitor L-NIL

Networked: 24 relevant articles (1 outcomes, 3 trials/studies)

1.	Parasitemia 04/01/2001 - "Parasitemia was cleared and tissue amastigotes became undetectable in these mice even in the presence of the iNOS inhibitor L-NIL. "
2.	Lung Injury 11/01/2004 - "This study investigated the capability of an exogenous nitric oxide (NO) donor, sodium nitroprusside (NP); a NO substrate, L-arginine; and an inducible NO synthase inhibitor, L-N6-(1-iminoethyl)lysine (L-NIL) to reduce lung injury in an animal model of mixed controlled and uncontrolled hemorrhagic shock. "
3.	Atherosclerosis 08/29/2000 - "This is the first study showing that chronic treatment with an iNOS inhibitor, L-NIL, limits progression of preexisting atherosclerosis in hypercholesterolemic rabbits. "
4.	Hemorrhagic Shock 11/01/2004 - "This study investigated the capability of an exogenous nitric oxide (NO) donor, sodium nitroprusside (NP); a NO substrate, L-arginine; and an inducible NO synthase inhibitor, L-N6-(1-iminoethyl)lysine (L-NIL) to reduce lung injury in an animal model of mixed controlled and uncontrolled hemorrhagic shock. "
5.	Pulmonary Hypertension 09/01/2007 - "A recent study showed that long-term administration of the inducible nitric oxide synthase (iNOS) inhibitor L-NIL reduced the development of pulmonary hypertension. "

1.	Nitric Oxide Synthase (NO Synthase)
2.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
3.	Nitric Oxide (Nitrogen Monoxide)
4.	Nitroprusside (Sodium Nitroprusside)
5.	Arginine (L-Arginine)
6.	Carrageenan
7.	NG-Nitroarginine Methyl Ester (L-NAME)
8.	Dexamethasone (Maxidex)
9.	Factor Xa Inhibitors
10.	Drinking Water