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tuberous sclerosis complex 2 protein (tuberin)

Subscribe to New Research on tuberous sclerosis complex 2 protein

involved in genetic predisposition to renal carcinoma; has been sequenced

Also Known As:

tuberin; TSC2 protein, human; Tsc2 protein, mouse; Tsc2 protein, rat; tuberin protein, human; tuberous sclerosis 2 protein; tuberous sclerosis 2 protein, human; tuberous sclerosis 2 protein, mouse; tuberous sclerosis 2 protein, rat

Networked: 250 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Neoplasm Proteins: 2
    - Tumor Suppressor Proteins: 254
      - tuberous sclerosis complex 2 protein: 250

Experts

1.	Habib, Samy L: 14 articles (08/2014 - 01/2008)
2.	Rosner, Margit: 9 articles (08/2013 - 12/2003)
3.	Hengstschläger, Markus: 9 articles (08/2013 - 12/2003)
4.	Yeung, Raymond S: 8 articles (11/2010 - 08/2002)
5.	Blenis, John: 7 articles (09/2013 - 07/2002)
6.	Hino, Okio: 7 articles (08/2013 - 11/2002)
7.	Walker, Cheryl Lyn: 7 articles (05/2010 - 03/2002)
8.	Mizuguchi, Masashi: 7 articles (03/2007 - 01/2002)
9.	Henske, Elizabeth Petri: 6 articles (09/2013 - 12/2003)
10.	Kobayashi, Toshiyuki: 6 articles (08/2013 - 11/2002)

Related Diseases

1.	Tuberous Sclerosis (Bourneville's Disease) 09/15/2011 - "Mimicking a mutation found in a subset of patients with tuberous sclerosis, we found a significant reduction in the binding between tuberin and cyclin B1. " 08/01/2013 - "Recent studies indicated that the tuberous sclerosis 2 (TSC2) gene product, tuberin, regulates Rac1 activity. " 06/01/2014 - "The TSC2 gene, mutated in patients with tuberous sclerosis complex (TSC), encodes a 200 kDa protein TSC2 (tuberin). " 06/01/2012 - "regulatory Thr/Tyr in Erks 1 and 2, Tyr in signal transducers and activators of transcription (Stat) 5a and 5b, Ser939 in tuberous sclerosis protein (TSC) 2 or tuberin). " 01/01/2012 - "Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin."
2.	Neoplasms (Cancer) 05/01/2008 - "In tumors that retained TSC2 expression, phosphorylation of tuberin at S939 was observed with a high frequency, indicating that mTOR repression by TSC2 had been relieved via AKT phosphorylation of this tumor suppressor. " 05/15/2014 - "In addition, a significant increase in phospho-Akt/tuberin expression was associated with an increase in Ki67 expression and activation of mTOR in kidney tumor with or without diabetes compared to diabetes alone. " 08/01/2013 - "To better understand the molecular link between tuberin function and Rac1, we characterized the activity and distribution of Rac1 in mouse Tsc2-deficient renal tumor cells using restoration experiments with wild-type tuberin. " 06/01/2013 - "This was accompanied by an inhibitory shift in the Akt/mTOR signaling pathway which included diminished expression and/or phosphorylation of Akt, mTOR, p70 S6K, and p85 S6K with increased activation of AMPKα and the tumor suppressor tuberin/TSC2. " 03/01/2012 - "These data allow new insights into the regulation of early stem-cell maintenance and differentiation and identify a new role of the tumor suppressor tuberin and the oncogenic protein PRAS40 with the relevance for a more detailed understanding of the pathogenesis of diseases associated with altered activities of these gene products."
3.	Breast Neoplasms (Breast Cancer) 07/01/2005 - "Tumours from patients who developed recurrence and died from breast cancer had significantly low levels of tuberin compared with those who remained disease free (P = 0.03 and 0.05, respectively). " 08/01/2013 - "Our results suggest that tuberin and p27 are aberrantly expressed in malignant tissue, but their expression does not appear to be dependent on the BRCA mutation state of a breast cancer patient." 08/01/2013 - "The expression of tuberin and p27 in breast cancer was not correlated with clinical outcome. " 08/01/2013 - "Tuberin and p27 protein expression were significantly more common in benign when compared to malignant breast tissue (p = 0.01 and p = 0.03), but no difference was observed when sporadic and BRCA-mutated breast cancer specimen were compared. " 08/01/2013 - "immunohistochemistry was used to compare p27 and tuberin protein expression in 26 BRCA1 and 2 mutation carriers, in 53 matched breast cancer patients without a family history, and in 74 benign breast tissues in a case-control study. "
4.	Astrocytoma (Pilocytic Astrocytoma) 01/01/2003 - "In this study, we compared levels of Rap1-GTP, Rap1 and tuberin levels in normal brain tissue and 24 grade II-IV astrocytoma specimens. " 09/25/1997 - "Previous studies from our laboratory demonstrated that 30% of sporadic astrocytomas have reduced or absent tuberin expression. " 02/01/2004 - "The subependymal giant cell astrocytomas of six of nine patients had no expression of tuberin as well, whereas three patients retained some tuberin expression. " 12/01/2003 - "Subependymal giant cell astrocytoma with positive tuberin expression--case report." 01/01/2003 - "Whereas Rap1 overexpression was observed in astrocytomas of all malignancy grades, tuberin loss was seen most frequently in the higher-grade astrocytomas. "
5.	Fibrosis (Cirrhosis) 08/30/2014 - "In the present study, we investigated the role of Akt/tuberin/mTOR pathway in the regulation cell fibrosis proteins. " 01/01/2013 - "In the present study, we investigated the potential role of tuberin/mTOR pathway in the regulation of cell fibrosis in AML cells and kidney tumor tissue from tuberous sclerosis complex (TSC) patients. " 01/01/2013 - "The mechanisms by which tuberin regulates fibrosis in kidney angiomyolipomas (AMLs) of tuberous sclerosis patients are not fully known. " 09/05/2005 - "Patients with tuberous sclerosis complex (TSC) develop hamartomatous tumors showing loss of function of the tumor suppressor TSC1 (hamartin) or TSC2 (tuberin) and increased angiogenesis, fibrosis, and abundant mononuclear phagocytes. " 08/30/2014 - "These data comprise the first report to provide the role of Akt/tuberin/mTORC1/2 in the regulation of N-cadherin and vimentin that are involved in the progression of fibrosis in kidney tumor of TSC patients. "

Related Drugs and Biologics

1.	tuberous sclerosis complex 1 protein (hamartin)
2.	Proteins (Proteins, Gene)
3.	Carbon Monoxide
4.	Sirolimus (Rapamycin)
5.	Staphylococcal Protein A (A, Protein)
6.	Messenger RNA (mRNA)
7.	Insulin (Novolin)
8.	8-oxo-7-hydrodeoxyguanosine
9.	AMP-Activated Protein Kinases
10.	Protein Kinases (Protein Kinase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)