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anastrozole (Arimidex)

Subscribe to New Research on anastrozole

trade name; aromatase inhibitor; structure given in first source

Also Known As:

Arimidex; 2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile); Astra brand of anastrozole; AstraZeneca brand of anastrozole; ICI D1033; ZD-1033; ZD1033; Zeneca ZD 1033; Zeneca brand of anastrozole; anastrazole; 1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-

Networked: 907 relevant articles (160 outcomes, 369 trials/studies)

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Drug Context: Research Results

Experts

1.	Cuzick, Jack: 39 articles (06/2015 - 01/2003)
2.	Dowsett, Mitch: 37 articles (06/2015 - 02/2002)
3.	Howell, Anthony: 33 articles (06/2015 - 04/2002)
4.	Buzdar, Aman U: 25 articles (07/2015 - 06/2002)
5.	Sestak, Ivana: 16 articles (06/2015 - 09/2008)
6.	Buzdar, Aman: 16 articles (06/2015 - 06/2002)
7.	Ingle, James N: 14 articles (07/2015 - 08/2002)
8.	Gnant, Michael: 14 articles (03/2015 - 08/2005)
9.	Dixon, J Michael: 14 articles (01/2013 - 06/2002)
10.	Jakesz, Raimund: 13 articles (01/2013 - 05/2003)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/01/2007 - "Efficacy of anastrozole on local recurrence in patients with favorable early breast cancer." 03/01/2013 - "[Three patients with local recurrence of ER-positive breast cancer for whom anastrozole was clinically effective]." 03/01/1996 - "Anastrozole is an effective and well tolerated treatment for postmenopausal patients with advanced breast cancer. " 10/01/2008 - "Anastrozole therapy is a useful treatment for postmenopausal woman with ER-positive recurrent breast cancer." 09/01/2002 - "Anastrozole therapy is a useful treatment for postmenopausal women with ER positive advanced breast cancer."
2.	Neoplasms (Cancer) 08/01/2008 - "Anastrozole was effective for the control of tumor growth and her symptoms. " 07/01/2011 - "In this study we set out to investigate the significance of intrinsic subtypes within a group of ER+ve breast cancers treated with neoadjuvant anastrozole. " 12/01/2003 - "Phase II trial of anastrozole in women with asymptomatic müllerian cancer." 11/15/2015 - "Formulation and evaluation of anastrozole, an anti-cancer drug loaded in different biodegradable polymeric nanoparticles. " 01/01/2015 - "This likely explains tumor progression on Anastrozole. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2014 - "She had been started on anastrozole in May 2013 for bony metastases, detected on a bone scan. " 08/06/2013 - "Normal weight patients with additional 3 years of anastrozole halved their risk of disease recurrence (disease-free survival (DFS) HR 0.48; P=0.02) and death (HR 0.45; P=0.06) and had only a fifth of the risk of distant metastases (HR 0.22; P=0.05) compared with normal weight patients without any further treatment. " 08/01/2006 - "Uterine metastases should be kept in mind in asymptomatic patients on anastrozole therapy." 12/01/2003 - "The results reveal anastrozole to be an effective and valuable first- and second-line therapy in postmenopausal women with ABC and visceral metastases, showing similar CB to other endocrine therapies." 12/01/2003 - "In patients with or without visceral metastases, second-line treatment with anastrozole resulted in a CB rate of 31.4 and 51.8%, respectively, compared with 31.9 and 47.1%, respectively, for those treated with MA. "
4.	Endometriosis (Adenomyosis) 06/01/2010 - "After the optimal time for SLW to inhibit invasion ability of endometrial cells was identified based on time-effect relationship, another endometrial cells were divided into six groups: hysteromyoma endometrium group, eutopic endometrium of endometriosis group, eutopic endometrium of endometriosis + middle dose of SLW serum group, eutopic endometrium of endometriosis + middle dose of SLW serum + E2 group, eutopic endometrium of endometriosis + anastrozole serum group , and eutopic endometrium of endometriosis + E2 group. " 03/01/2010 - "After the optimal time for SLW to induce apoptosis of eutopic endometrial cells of endometriosis in early stage and late stage was identified based on time-effect relationship, another endometrium cells were divided into six groups: hysteromyoma endometrium group, eutopic endometrium of endometriosis group, eutopic endometrium of endometriosis + middle dose of SLW serum group, eutopic endometrium of endometriosis + anastrozole serum group, eutopic endometria of endometriosis + middle dose of SLW serum + E2 group and eutopic endometrium of endometriosis + E2 group. " 05/01/2015 - "Aromatase inhibitor (anastrozole) may be an effective treatment for endometriosis due to inhibition of cellular aromatase." 08/01/2005 - "Anastrazole and oral contraceptives: a novel treatment for endometriosis." 01/01/2004 - "In a prospective randomized trial, we evaluated the efficacy of using either a combination of anastrozole and goserelin for 6 months or goserelin alone for 6 months after conservative surgery for severe endometriosis. "
5.	Carcinoma (Carcinomatosis) 01/01/2013 - "The aim was to investigate the impact of the genetic polymorphisms, CYP19A1, 17-β-HSD-1 and FTO, on the response to anastrozole in metastatic breast carcinoma (MBC) and to evaluate the impact of those polymorphisms on various clinicopathologic features. " 07/01/2009 - "To our knowledge, this is the second case of lobular breast carcinoma metastasized to the uterus under anastrozole therapy. " 01/01/2007 - "Thereafter she continued adjuvant treatment for breast carcinoma with anastrazole. " 08/01/2006 - "This is the first report of breast carcinoma metastatic to the endometrium in a patient on adjuvant anastrozole therapy. " 01/01/2013 - "Cyberknife radiotherapy and anastrozole for the treatment of advanced progressive low-grade papillary serous ovarian carcinoma: A case report."

Related Drugs and Biologics

1.	Tamoxifen
2.	letrozole (Femara)
3.	Hormones
4.	anastrozole (Arimidex)
5.	exemestane (Aromasin)
6.	Aromatase (CYP19)
7.	Aromatase Inhibitors
8.	fulvestrant (Faslodex)
9.	Estrogens (Estrogen)
10.	Goserelin (Zoladex)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Aftercare (After-Treatment)
4.	Segmental Mastectomy (Lumpectomy)
5.	Radiotherapy