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steroidogenic acute regulatory protein

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a luteinizing hormone-induced mitochondrial protein isolated from murine Leydig tumor cells; also found in normal tissues; amino acid sequence in first source

Also Known As:

STAR protein, human; STARD1 protein, human; Star protein, mouse; Star protein, rat; star protein, zebrafish; steroidogenic acute regulator protein, human; steroidogenic acute regulatory protein, mouse; steroidogenic acute regulatory protein, rat; steroidogenic acute regulatory protein, zebrafish

Networked: 109 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Phosphoproteins: 284
    - steroidogenic acute regulatory protein: 109

Experts

1.	Miller, Walter L: 4 articles (02/2015 - 12/2006)
2.	Achermann, John C: 4 articles (07/2010 - 09/2005)
3.	Stocco, Douglas M: 4 articles (01/2009 - 11/2002)
4.	Manna, Pulak R: 4 articles (01/2009 - 02/2002)
5.	Tsai, Shaw-Jenq: 3 articles (10/2006 - 09/2003)
6.	Mol, J A: 2 articles (07/2014 - 11/2010)
7.	Wang, Yubang: 2 articles (01/2013 - 12/2006)
8.	Morel, Yves: 2 articles (05/2012 - 09/2005)
9.	Mallet, Delphine: 2 articles (05/2012 - 09/2005)
10.	Mullis, Primus E: 2 articles (01/2011 - 09/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2006 - "Several factors have been identified in the transcriptional repression of the steroidogenic acute regulatory protein (StAR) gene promoter; yet, no associating corepressor complexes have been characterized for the mouse promoter in MA-10 mouse Leydig tumor cells. " 07/18/2003 - "Steroidogenic acute regulatory protein expression in the normal human brain and intracranial tumors." 11/01/1997 - "Inhibition of transcription affects synthesis of steroidogenic acute regulatory protein and steroidogenesis in MA-10 mouse Leydig tumor cells." 01/01/2013 - "The aim of present study was to elaborate the role of transcription factors and steroidogenic acute regulatory protein in low-dose MBP-induced distruption of steroidogenesis in mouse Leydig tumor cells (MLTC-1 cells). " 07/18/2003 - "In this study we found the expression of steroidogenic acute regulatory protein (StAR) mRNA and protein in both the normal human brain and intracranial tumors, using RT-PCR and immunohistochemistry. "
2.	Endometriosis (Adenomyosis) 09/01/2009 - "This study was designed to investigate the levels of expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis, and to explore the association between these two factors and the menstrual cycle and the severity of endometriosis. " 09/01/2009 - "Expression of steroidogenic factor 1 (SF-1) and steroidogenic acute regulatory protein (StAR) in endometriosis is associated with endometriosis severity." 09/01/2003 - "Steroidogenic acute regulatory protein (StAR) regulates the first committed step in the biosynthesis of steroids, and thus aberrant expression of StAR in endometriotic implants plays a critical role in the etiology of endometriosis. " 12/01/2001 - "The regulation of steroidogenic acute regulatory protein (StAR) gene expression and the synthesis of steroids from cholesterol in ectopic endometriosis tissues were investigated. "
3.	Adrenocortical Carcinoma 04/01/2012 - "In conclusion, this study demonstrates a novel insight into intracellular mechanism of VLDL-mediated aldosterone synthesis through transcriptional regulation of steroidogenic acute regulatory protein (StAR) and Cyp11B2 expression in human adrenocortical carcinoma cell line." 09/01/2003 - "Treatment of cultured adrenocortical carcinoma NCI-H295R cells with activin A inhibited steroidogenic acute regulatory protein and 17alpha-hydroxylase/17,20-lyase mRNA accumulation as evaluated by the Northern blot technique, and decreased cortisol, androstenedione, dehydroepiandrosterone and dehydroepiandrosterone sulfate secretion as determined by specific enzyme immunoassays. "
4.	Ischemia 06/30/2010 - "In order to study improvement of folliculogenesis after ovarian ischemia, steroidogenic acute regulatory protein (StAR), p44/p42 MAPK (T-ERK1/2), and phospho-p44/ p42 MAPK (P-ERK1/2) expression were specifically evaluated. " 07/01/2009 - "The expression of TSPO and its partners in steroidogenic cells, steroidogenic acute regulatory protein (StAR) and cytochrome P-450 side chain cleavage CYP11A1, as well as the impact of TSPO overexpression and exposure to TSPO ligands in vitro in hypoxia-ischemia conditions were investigated. "
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2010 - "The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity and expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (P450scc) in normal adult rats. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Cholesterol Side-Chain Cleavage Enzyme (CYP11A1)
3.	Aldosterone
4.	Transcription Factors (Transcription Factor)
5.	Aldosterone Synthase (CYP11B2)
6.	Steroidogenic Factor 1
7.	Mitogen-Activated Protein Kinase 1 (p42 MAP Kinase)
8.	Insulin (Novolin)
9.	Histones (Histone)
10.	Dexamethasone (Maxidex)