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4- (3,4,4- trimethyl- 5- oxo- 2- thioxo- 1- imidazolidinyl)- 2- (trifluoromethyl)benzonitrile

a non-steroidal antiandrogen; structure given in first source

Also Known As:

RU 56187; RU-56187; Benzonitrile, 2-(trifluoromethyl)-4-(3,4,4-trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - 4-(3,4,4-trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile: 1
Organic Chemicals: 133
- Nitriles: 227
  - 4-(3,4,4-trimethyl-5-oxo-2-thioxo-1-imidazolidinyl)-2-(trifluoromethyl)benzonitrile: 1

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 08/01/1998 - "The conclusions are: (1) the sets of responses of cell proliferation to three androgen-receptor ligands are cell specific; (2) the control of c-myc messenger RNA by R 1881 and RU 56187 may be related to the inhibition of cell proliferation by these compounds but not to their stimulatory effect on cell proliferation; (3) if prostate tumor cells would respond in vivo to androgens and antiandrogens like in culture, patients with prostate cancer could take benefits of reversible medical castration and sequential prescription of various antiandrogens."
2.	Neoplasms (Cancer) 08/01/1998 - "The conclusions are: (1) the sets of responses of cell proliferation to three androgen-receptor ligands are cell specific; (2) the control of c-myc messenger RNA by R 1881 and RU 56187 may be related to the inhibition of cell proliferation by these compounds but not to their stimulatory effect on cell proliferation; (3) if prostate tumor cells would respond in vivo to androgens and antiandrogens like in culture, patients with prostate cancer could take benefits of reversible medical castration and sequential prescription of various antiandrogens."

Related Drugs and Biologics

1.	Metribolone
2.	Messenger RNA (mRNA)
3.	Androgen Receptors (Androgen Receptor)
4.	Ligands
5.	Androgens
6.	Androgen Antagonists (Antiandrogens)

Related Therapies and Procedures

1.	Castration