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9- (2- phosphonylmethoxypropyl)- 2,6- diaminopurine
structure in first source
Also Known As:
9-(2-phosphonylmethoxypropyl)diaminopurine; PMPDAP
Networked:
6
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Purines: 651
Adenine: 2120
9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine: 6
Organic Chemicals: 133
Organophosphorus Compounds: 300
9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine: 6
Experts
1.
Hartmann, K
: 1 article (11/2012)
2.
Justa, N
: 1 article (11/2012)
3.
Klein, D
: 1 article (11/2012)
4.
Mueller, R S
: 1 article (11/2012)
5.
Sauter-Louis, C
: 1 article (11/2012)
6.
Weber, K
: 1 article (11/2012)
Related Diseases
1.
Infections
12/01/1995 - "
Also, PMEA and PMEDAP proved highly active against HHV-6 infection, whereas (S)-FPMPA and (R)-PMPDAP were inactive.
"
03/01/1995 - "
The antiviral efficacy of acyclic nucleoside phosphonates, including 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine [(R)-PMPDAP] against feline immunodeficiency virus (FIV) infection was determined.
"
2.
Neoplasms (Cancer)
02/01/1993 - "
When administered intraperitoneally at a single dose as low as 2 mg/kg, (R)-PMPDAP efficiently decreased MSV-induced tumor formation in newborn NMRI mice and significantly increased the survival time of MSV-infected mice.
"
3.
Necrosis
09/01/1997 - "
PMEG, (R)-PMPA, and (S)-PMPA greatly enhanced the secretion of both tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10), (R)-PMPDAP stimulated only TNF-alpha, other test compounds were ineffective.
"
4.
Body Weight (Weight, Body)
08/01/1996 - "
Nine asymptomatic cats that had been experimentally infected 3.5 to 4.5 years earlier had copy numbers between 5.6 x 10(3) and 4.3 x 10(4) per ml. Cats treated for six weeks with 9-(2-phosphonylmethoxy-propyl)-2,6-diaminopurine [PMPDAP] (20 mg/kg body weight s.c.
"
5.
Anemia
11/01/2012 - "
Administration of PMPDAP was not associated with significant improvements in clinical, immunological, or virological parameters, but treatment was associated with adverse effects, mainly anemia.
"
Related Drugs and Biologics
1.
Organophosphonates (Phosphonates)
2.
Nucleosides
3.
Antiviral Agents (Antivirals)
4.
adefovir
5.
Interleukin-10 (Interleukin 10)
6.
Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.
9-((2-phosphonylmethoxy)ethyl)guanine
8.
9- (2- phosphonylmethoxyethyl)- 2,6- diaminopurine
9.
Aligeron (AS 2)