plagiochilin A

converted to the hot-tasting compounds plagiochilal B and furanoplagiochilal by saliva; structure in first source; RN refers to (4R-(4alpha,4aalpha,5beta,7abeta,8abeta,8balpha))-isomer

Also Known As:

plagiochiline A

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ethers: 242
  - Cyclic Ethers: 12
    - Epoxy Compounds: 689
      - plagiochilin A: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - plagiochilin A: 3

Experts

1.	Aponte, José C: 1 article (06/2018)
2.	Bates, Paula J: 1 article (06/2018)
3.	Casson, Lavona K: 1 article (06/2018)
4.	Hammond, Gerald B: 1 article (06/2018)
5.	Islam, Ashraful: 1 article (06/2018)
6.	Reyes-Reyes, Elsa M: 1 article (06/2018)
7.	Stivers, Nicole S: 1 article (06/2018)
8.	Vaisberg, Abraham J: 1 article (06/2018)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/12/2018 - "Here, we have evaluated the effects of plagiochiline A on cell cycle progression in DU145 prostate cancer cells. " 03/10/2023 - "This unique, innovative mechanism of action, coupled with its marked anticancer action, notably against prostate cancer cells, make plagiochilin A an interesting lead molecule for the development of novel anticancer agents. "
2.	Neoplasms (Cancer) 06/01/1998 - "Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 microgram/ml. Plagiochiline A also showed cytotoxic activity. "
3.	Leukemia 06/01/1998 - "Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 microgram/ml. Plagiochiline A also showed cytotoxic activity. "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)
2.	octanoic acid (caprylic acid)