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bis(pivaloyloxymethyl)- 9- (2- phosphonylmethoxyethyl)adenine

structure given in first source

Also Known As:

bis(POM)-PMEA; bis(pivaloyloxymethyl)PMEA

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine: 5

Experts

1.	Civitico, G: 1 article (03/2000)
2.	Colledge, D: 1 article (03/2000)
3.	Locarnini, S: 1 article (03/2000)
4.	Shaw, T: 1 article (03/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1996 - "Oral treatment with bis(POM)-PMEA at a dose equivalent to 100 or 50 mg of PMEA per kg of body weight per day proved markedly effective in delaying MSV-induced tumor formation and death of the mice. "
2.	Body Weight (Weight, Body) 01/01/1996 - "Oral treatment with bis(POM)-PMEA at a dose equivalent to 100 or 50 mg of PMEA per kg of body weight per day proved markedly effective in delaying MSV-induced tumor formation and death of the mice. "
3.	Infections 03/01/2000 - "Lamivudine has recently received approval for clinical use against chronic human HBV infection, and both PCV and PMEA have undergone clinical trials against HBV in their respective prodrug forms (famciclovir and adefovir dipivoxil [bis-(POM)-PMEA]). " 08/01/1998 - "Adefovir dipivoxil [9-(2-(bispivaloyloxymethyl)phosphonylmethoxyethyl)adenine (bis-POM PMEA)], an oral prodrug of adefovir (PMEA), is currently in phase III clinical testing for the treatment of human immunodeficiency virus-1 (HIV-1) infection. "
4.	Arthritis (Polyarthritis) 11/24/1995 - "9-(2-phosphonomethoxyethyl)adenine (PMEA), its bis(pivaloyloxymethyl)ester (Bis-POM-PMEA), and 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl) cytosine (HPMPC) was investigated in the rat model of mycobacterial adjuvant-induced arthritis. " 07/02/1999 - "Antiarthritic effects of two acyclic nucleoside phosphonates, 9-(2-phosphonomethoxyethyl)adenine (PMEA; Adefovir) and 9-(2-phosphonomethoxypropyl)adenine (PMPA), as well as their more bioavailable prodrugs, bis(pivaloyloxymethyl)ester of PMEA [bis(POM)-PMEA; Adefovir Dipivoxil] and bis(isopropyloxycarbonyloxymethyl)ester of PMPA [bis(POC)-PMPA], were investigated in a model of adjuvant-induced arthritis in Lewis rats. "
5.	Splenomegaly 01/01/1996 - "Similarly, in mice infected with Friend leukemia virus (FLV), oral treatment with bis(POM)-PMEA at a dose equivalent to 100 or 50 mg of PMEA per kg per day effected a marked inhibition of FLV-induced splenomegaly (87 and 48% inhibition, respectively), the efficacy being equal to that of PMEA given subcutaneously at equivalent doses. "

Related Drugs and Biologics

1.	Prodrugs
2.	adefovir dipivoxil (Hepsera)
3.	Lamivudine (Epivir)
4.	Famciclovir (Famvir)
5.	adefovir
6.	Esters
7.	Organophosphonates (Phosphonates)
8.	Nucleosides
9.	Cytosine
10.	Adenine