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DD 003
structure given in first source
Also Known As:
22(S)-24-homo-26,26,26,27,27,27-hexafluoro-1alpha,22,25-trihydroxyvitamin D3; DD-003; Nickel alloy, base, Ni,Al,Co,Cr,Mo,Ti,W (DD3)
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Secosteroids: 22
Vitamin D: 33265
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
DD 003: 2
Cholestanes
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
DD 003: 2
Cholestenes
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
DD 003: 2
Lipids: 114793
Membrane Lipids: 1591
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
DD 003: 2
Related Diseases
1.
Colonic Neoplasms (Colon Cancer)
03/01/1996 - "
[Colon cancer and vitamin D--in vivo growth inhibition of colon cancer by a fluorinated analogue of 1,25-(OH)2D3, DD-003].
"
10/01/1994 - "
Since chemosensitivity tested by the subrenal capsule assay correlates well with clinical response, DD-003 may be clinically applicable in procedures such as postsurgical chemotherapy of colon cancer.
"
10/01/1994 - "
Inhibition of HT-29 human colon cancer growth under the renal capsule of severe combined immunodeficient mice by an analogue of 1,25-dihydroxyvitamin D3, DD-003.
"
2.
Neoplasms (Cancer)
10/01/1994 - "
When DD-003 was withdrawn after 2 weeks of treatment, tumor growth resumed.
"
10/01/1994 - "
Administration of DD-003 inhibited growth of HT-29 tumor by 63%.
"
10/01/1994 - "
Tumors in DD-003 treated mice were smaller with less invasion compared to the control.
"
10/01/1994 - "
Starting 7 days after implantation of HT-29 tumor, mice were given 3 micrograms/kg body weight of DD-003 or the vehicle i.p.
"
10/01/1994 - "
DD-003 inhibited growth of HT-29 tumor in a dose-dependent manner over the range of 0.1-10 micrograms/kg body weight, with no increase of serum calcium concentration observed at any dose level.
"
3.
Body Weight (Weight, Body)
10/01/1994 - "
Starting 7 days after implantation of HT-29 tumor, mice were given 3 micrograms/kg body weight of DD-003 or the vehicle i.p.
"
10/01/1994 - "
DD-003 inhibited growth of HT-29 tumor in a dose-dependent manner over the range of 0.1-10 micrograms/kg body weight, with no increase of serum calcium concentration observed at any dose level.
"
Related Drugs and Biologics
1.
Vitamin D
2.
Capsules (Microcapsules)
3.
Calcium
4.
Calcitriol (Calcijex)
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)