cylindrospermopsin

a cyanobacterial alkaloid; isolated from blue-green alga UMEZAKIA NATANS; has a tricyclic guanidine moiety combined with hydroxymethyluracil; structure given in first source; RN - from Toxlit

Also Known As:

2,4(1h,3h)-pyrimidinedione, 6-((R)-hydroxy((2AS,3R,4S,5AS,7R)-2,2A,3,4,5,5A,6,7-octahydro-3-methyl-4-(sulfooxy)-1h-1,8,8B-triazaacenaphthylen-7-yl)methyl)-; 7-Epicylindrospermopsin; 7-epi-cylindrospermopsin; cylindrospermopsine

Networked: 39 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	de Magalhães, Valéria Freitas: 2 articles (10/2022 - 04/2015)
2.	Filipič, Metka: 2 articles (12/2020 - 09/2013)
3.	Cameán, A M: 2 articles (03/2020 - 06/2019)
4.	Gutiérrez-Praena, D: 2 articles (03/2020 - 06/2019)
5.	Hinojosa, M G: 2 articles (03/2020 - 06/2019)
6.	Jos, A: 2 articles (03/2020 - 06/2019)
7.	Moreno, F J: 2 articles (03/2020 - 06/2019)
8.	Prieto, A I: 2 articles (03/2020 - 06/2019)
9.	Fastner, Jutta: 2 articles (01/2020 - 02/2010)
10.	Filipak Neto, Francisco: 2 articles (09/2016 - 04/2015)

Related Diseases

1.	Poisoning 07/01/1994 - "Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans." 02/05/2023 - "Cylindrospermopsin (CYN), a cyanotoxin occurring in environmental waters as a cyanobacteria metabolite, has recently raised increased interest both in the scientific community and the environmental, food control and health care bodies due to the incidence of poisoning reports and the lack of prompt, effective detection and monitoring techniques. " 10/01/2022 - "Cylindrospermopsin (CYN) is a water-soluble cyanotoxin that has been linked to several cases of poisoning in the world. " 06/15/2021 - "Cylindrospermopsin (CYN) has been involved in cases of poisoning in humans following ingestion. " 06/01/2021 - "The cyanotoxin cylindrospermopsin (CYN) is the second biggest cause of poisoning worldwide, both in humans and animals. "
2.	Shellfish Poisoning 01/01/2003 - "The relationship between toxicity and the observed HIP1 polymerase chain reaction fingerprint profiles was less clear, although it is interesting to note that of the strains analysed in this study, only Australian strains are known to produce cylindrospermopsin and only Brazilian strains have been reported to produce paralytic shellfish poisoning toxins." 08/01/2011 - "Due to its known ability to produce potent toxins, such as cylindrospermopsin and the paralytic shellfish poisoning, this species is of major concern from a water quality perspective. " 10/01/2004 - "Cylindrospermopsis raciborskii is a cyanobacterium which produces either cylindrospermopsine or paralytic shellfish poisoning (PSP) toxins. " 02/01/2010 - "Neurotoxic paralytic shellfish poisoning (PSP) toxins, anatoxin-a (ATX), and hepatotoxic cylindrospermopsin (CYN) have been detected in several lakes in northeast Germany during the last 2 decades. " 02/16/2010 - "Cylindrospermopsis raciborskii CS-505 is a cylindrospermopsin-producing strain from Australia, whereas Raphidiopsis brookii D9 from Brazil synthesizes neurotoxins associated with paralytic shellfish poisoning (PSP). "
3.	Inflammation (Inflammations) 10/01/2012 - "In conclusion, cylindrospermopsin exposure impaired lung mechanics, which was preceded by lung parenchyma inflammation and oxidative stress." 12/01/2022 - "Subchronic Oral Cylindrospermopsin Exposure Alters the Host Gut Microbiome and Is Associated with Progressive Hepatic Inflammation, Stellate Cell Activation, and Mild Fibrosis in a Preclinical Study."
4.	Dysbiosis 12/01/2022 - "In conclusion, the present study provides additional evidence of cylindrospermopsin-linked progressive liver pathology that may be very well-linked to gut dysbiosis, though definitive evidence involving this link needs to be studied further." 12/01/2022 - "A known hepatotoxin in higher concentrations, we examined the possible role of cylindrospermopsin in causing host gut dysbiosis and its association with liver pathology in a mouse model of toxico-pharmacokinetics and hepatic pathology. "
5.	Starvation 06/01/2006 - "The present study is the first concerning the cylindrospermopsin content under sulfate starvation and discusses it in relation to phosphorous starvation." 06/01/2006 - "Sulfate starvation induced a characteristic reduction of cylindrospermopsin pool size on the basis of cell number and unit of dry mass of culture. "

Related Drugs and Biologics

1.	Sulfates (Sulfates, Inorganic)
2.	Microcystins
3.	anatoxin a
4.	cyanoginosin LR (microcystin LR)
5.	Drinking Water
6.	Neurotoxins
7.	Chlorpyrifos (Lorsban)
8.	anatoxin-a(s)
9.	Therapeutic Uses
10.	Reactive Oxygen Species (Oxygen Radicals)