N-acetyltransferase 1

a xenobiotic enzyme that metabolizes inhaled or ingested carcinogenic compounds; RefSeq NM_000662 (human); NM_008673 (mouse); NM_001037315 (rat)

Also Known As:

AAC1 protein, human; N-acetyl transferase 1, human; N-acetyltransferase 1 (arylamine N-acetyltransferase) protein, mouse; N-acetyltransferase 1 (arylamine N-acetyltransferase), rat; N-acetyltransferase 1, human; N-acetyltransferase 1, rat; N-acetyltransferase-1; NAT1 protein, human; Nat1 protein, mouse; Nat1 protein, rat; arylamide acetylase 1; arylamine N-acetyltransferase 1

Networked: 120 relevant articles (1 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hein, David W: 29 articles (01/2022 - 01/2002)
2.	Doll, Mark A: 24 articles (01/2022 - 01/2002)
3.	Butcher, Neville J: 12 articles (01/2022 - 05/2004)
4.	Minchin, Rodney F: 12 articles (01/2022 - 05/2004)
5.	States, J Christopher: 8 articles (01/2018 - 07/2004)
6.	Sim, Edith: 7 articles (01/2013 - 09/2003)
7.	Carlisle, Samantha M: 6 articles (01/2021 - 07/2016)
8.	Stepp, Marcus W: 5 articles (01/2019 - 07/2016)
9.	Morton, Lindsay M: 5 articles (01/2013 - 08/2006)
10.	Salazar-González, Raúl A: 4 articles (01/2022 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 05/21/2004 - "Many drugs and chemicals found in the environment are either detoxified by N-acetyltransferase 1 (NAT1, EC 2.3.1.5) and eliminated from the body or bioactivated to metabolites that have the potential to cause toxicity and/or cancer. " 01/01/2019 - "Human arylamine N-acetyltransferase 1 (NAT1) has been widely reported to affect cancer cell growth and survival and recent studies suggest it may alter cell metabolism. " 01/01/2019 - "Background: The N-acetyltransferase 1 (NAT1) gene is downregulated in several cancers and associated with patient survival. " 01/01/2018 - "Arylamine N-acetyltransferase 1 (NAT1) expression is reported to affect proliferation, invasiveness, and growth of cancer cells. " 01/01/2018 - "Human arylamine N-acetyltransferase 1 (NAT1) has been associated with cancer cell growth and invasion, but the underlying molecular mechanisms remain unknown. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Recent studies found that arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer, further suggesting NAT1 could be a potential therapeutic target for breast cancer. " 01/01/2022 - "Previous studies have shown that inhibition or depletion of N-acetyltransferase 1 (NAT1) in breast cancer cell lines leads to growth retardation both in vitro and in vivo, suggesting that NAT1 contributes to rapid growth of breast cancer cells. " 12/01/2022 - "Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. " 12/01/2022 - "Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells." 01/01/2022 - "Arylamine N-acetyltransferase 1 (NAT1) is frequently upregulated in breast cancer. "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 07/24/2017 - "Individual studies of the association between N-acetyltransferase 1 (NAT1)10 allele and bladder cancer susceptibility have shown inconclusive results. " 07/24/2017 - "Association of N-acetyltransferase 1 polymorphism and bladder cancer risk: an updated meta-analysis and trial sequential analysis." 01/01/2017 - "In a large bladder cancer study in the greater Berlin area with 425 cases and 343 controls, the haplotype N-acetyltransferase 110 (NAT110) was associated with a decreased bladder cancer risk. " 01/01/2017 - "N-acetyltransferase 110 genotype in bladder cancer patients." 02/01/2013 - "This meta-analysis was conducted to summarize the association between an N-acetyltransferase 1 (NAT1) gene polymorphism and bladder cancer risk. "
4.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2012 - "Published data on the association between N-acetyltransferase 1 (NAT1) gene polymorphisms and colorectal carcinoma (CRC) susceptivity are inconclusive. " 01/01/2009 - "The colorectal cancer risk was significantly increased in rapid N-acetyltransferase 1 carriers with high white meat consumption (almost every day) compared to those carrying the slow N-acetyltransferase 1 genotype with low white meat consumption (less than once a week, odds ratio, 3.00; 95 percent confidence interval, 1.83-4.92). " 05/30/2007 - "Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma." 04/01/1997 - "These compounds are acetylated by N-acetyltransferase 1 (NAT1) and 2 (NAT2), and epidemiological studies have shown that the slow NAT2 acetylator phenotype is associated with increased risk of bladder cancer and may be associated with decreased risk of colorectal cancer. " 01/01/2012 - "There have been an increasing number of studies with evidence suggesting that the N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) genotypes may be implicated in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). "
5.	Adenoma (Adenomas) 01/01/2012 - "There have been an increasing number of studies with evidence suggesting that the N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2) genotypes may be implicated in the development of colorectal cancer (CRC) and colorectal adenoma (CRA). " 02/01/2008 - "Using data from the Tennessee Colorectal Polyp Study, a large colonoscopy-based study, including 1,002 polyp cases (557 adenoma only, 250 hyperplastic polyp only, 195 both polyps) and 1,493 polyp-free patients, we evaluated the association of colorectal polyp risk with carcinogen exposure from meat and genetic polymorphisms in enzymes involved in heterocyclic amine (HCA) metabolism, including N-acetyltransferase 1 (NAT1) and N-acetyltransferase 2 (NAT2), cytochrome P450 1A2 (CYP1A2), and aryl hydrocarbon receptor (AhR). "

Related Drugs and Biologics

1.	Enzymes
2.	Acetyltransferases
3.	Amines
4.	Carcinogens
5.	Xenobiotics
6.	Cytochrome P-450 CYP1A2 (CYP1A2)
7.	Cytochrome P-450 Enzyme System (Cytochrome P450)
8.	MicroRNAs (MicroRNA)
9.	Peroxynitrous Acid (Peroxynitrite)
10.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)