protein kinase D

a target for phorbol esters and diacylglycerols; an isoform of protein kinase C; RefSeq NM_002742 (human); NM_008858 (mouse); XM_234108 (rat); do not confuse with Pkd1 protein, mouse

Also Known As:

PKCmu; PKD1 kinase, mouse; PKD1 kinase, rat; PRKCM protein, human; PRKD1 protein, human; Pkcm protein, mouse; Prkcm protein, mouse; Prkcm protein, rat; protein kinase C mu; protein kinase C, mu, human; protein kinase C, mu, mouse; protein kinase C, mu, rat; protein kinase Cmu; protein kinase D1, human; protein kinase D1, mouse; protein kinase D1, rat

Networked: 128 relevant articles (2 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wang, Qiming Jane: 9 articles (01/2021 - 01/2012)
2.	Wang, Q Jane: 8 articles (11/2018 - 05/2010)
3.	Wipf, Peter: 8 articles (03/2015 - 05/2010)
4.	Deng, Fan: 6 articles (03/2019 - 01/2015)
5.	Xu, Shuping: 6 articles (11/2018 - 08/2011)
6.	Storz, Peter: 6 articles (02/2016 - 01/2009)
7.	Pandol, Stephen J: 5 articles (11/2022 - 01/2011)
8.	Yuan, Jingzhen: 5 articles (11/2022 - 01/2011)
9.	Zhao, Zhuo: 5 articles (01/2020 - 01/2010)
10.	Tandon, Manuj: 5 articles (11/2018 - 01/2012)

Related Diseases

1.	Heart Failure 12/01/2021 - "Protein kinase D (PKD) consists of a family of three structurally related enzymes that play key roles in a wide range of biological functions that contribute to the evolution of cardiac hypertrophy and heart failure. " 03/28/2008 - "Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure." 06/01/2014 - "Here, we focus on the disease-specific regulation of a number of protein kinases, namely, Ca(2+)/calmodulin-dependent protein kinase II isoform δ (CaMKIIδ), G protein-coupled receptor kinase 2 (GRK2), extracellular signal-regulated kinase 1 and 2 (ERK1/2), protein kinase D (PKD) and protein kinase C isoform β2 (PKCβ2), which are embedded in complex signal transduction pathways implicated in heart failure development, and discuss potential avenues for novel treatment strategies to combat heart disease. "
2.	Heart Diseases (Heart Disease) 01/01/2012 - "Protein kinase D (PKD) has emerged as a potential therapeutic target in multiple pathological conditions, including cancer and heart diseases. " 06/01/2014 - "Here, we focus on the disease-specific regulation of a number of protein kinases, namely, Ca(2+)/calmodulin-dependent protein kinase II isoform δ (CaMKIIδ), G protein-coupled receptor kinase 2 (GRK2), extracellular signal-regulated kinase 1 and 2 (ERK1/2), protein kinase D (PKD) and protein kinase C isoform β2 (PKCβ2), which are embedded in complex signal transduction pathways implicated in heart failure development, and discuss potential avenues for novel treatment strategies to combat heart disease. "
3.	Diabetic Cardiomyopathies 03/01/2015 - "Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model."
4.	Type 2 Diabetes Mellitus (MODY) 03/01/2015 - "Irbesartan ameliorates diabetic cardiomyopathy by regulating protein kinase D and ER stress activation in a type 2 diabetes rat model."
5.	Neoplasms (Cancer) 12/31/2022 - "In search of such targets, we focused on protein kinase D (PKD), which is suggested to be suppressive in both tumor growth and TCR signaling. " 11/01/2020 - "The multiple roles of protein kinase D (PKD) in various cancer hallmarks have been repeatedly reported. " 07/01/2019 - "Additionally, molecular analyses of PAC specimens indicate that the PAC spectrum phenotypes result from different genotypes (protein kinase D positive; PRKD(+) and PRKD(-) tumors). " 01/01/2019 - "Protein kinase D (PKD) has been implicated in cancer cell survival, proliferation, migration and angiogenesis. " 01/01/2019 - "Protein kinase D (PRKD) family members play crucial roles in cancer progression. "

Related Drugs and Biologics

1.	Protein Kinase C
2.	Protein Isoforms (Isoforms)
3.	Calcium-Calmodulin-Dependent Protein Kinases
4.	Protein Kinases (Protein Kinase)
5.	Mitogen-Activated Protein Kinase 3
6.	G-Protein-Coupled Receptor Kinase 2
7.	Irbesartan
8.	Atorvastatin (Lipitor)
9.	protein kinase D
10.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy