flezelastine

an anti-asthmatic/anti-allergic agent; structure in first source

Also Known As:

4-((4-fluorophenyl)methyl)-2-(hexahydro-1-(phenylethyl)-1H-azepin-4-yl)-1-2H-phthalazinone hydrochloride; flezelastine hydrochloride

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Glioblastoma (Glioblastoma Multiforme) 07/17/1995 - "The effects of two new phthalazinone derivatives, azelastine (AZ) and flezelastine (FZ), on the reversal of resistance to doxorubicin (dox) were studied using two variants of the rat C6 glioblastoma cell line, selected with dox (C6 0.5) or with vincristine (C6 1V). "
2.	Fever (Fevers) 03/01/1994 - "In vivo, LPS-induced fever in rats, which is at least partly driven by the release of IL-1 beta, was also inhibited by flezelastine. " 03/01/1994 - "Effects of flezelastine and its enantiomers on LPS-induced IL-1 beta generation in vitro and LPS-induced pyrexia in vivo."

1.	Interleukin-1beta (Interleukin 1 beta)
2.	Vincristine (Oncovin)
3.	Doxorubicin (Adriamycin)
4.	azelastine (Optivar)