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2- acetamido- 1,3,6- tri- O- acetyl- 4- deoxy- 4- fluoroglucopyranose

Also Known As:

2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-alpha-D-glucopyranose; 4-F-GlcNAc

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Amino Sugars: 110
  - Hexosamines: 733
    - Glucosamine: 1771
      - Acetylglucosamine: 922
        2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoroglucopyranose: 6

Experts

1.	Dimitroff, Charles J: 5 articles (02/2012 - 01/2003)
2.	Barthel, Steven R: 2 articles (02/2012 - 12/2007)
3.	Descheny, Leyla: 2 articles (12/2007 - 09/2006)
4.	Gainers, Madeliene E: 2 articles (12/2007 - 09/2006)
5.	Sackstein, Robert: 2 articles (10/2003 - 01/2003)
6.	Cedeno-Laurent, Filiberto: 1 article (02/2012)
7.	Frank, Markus H: 1 article (02/2012)
8.	Hays, Danielle: 1 article (02/2012)
9.	He, Xiaoying: 1 article (02/2012)
10.	Matta, Khushi L: 1 article (02/2012)

Related Diseases

1.	Carcinoma (Carcinomatosis) 09/09/1994 - "In this study, we report that adhesion of human ovarian carcinoma cells to polystyrene plates coated with polymerized human splenic galaptin can be inhibited by polyclonal antibodies raised against lamp-1 and lamp-2 molecules and by pretreatment of A-121 human ovarian carcinoma cells with glucosamine analogs: 2-acetamido-1,4,6-tri-O-acetyl-3- deoxy-3-fluoro-alpha-D-glucopyranose (3-F-GlcNAc) and 2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoro-alpha-D-glucopyranose (4-F-GlcNAc). "
2.	Neoplasms (Cancer) 01/15/2003 - "These observations establish a potential treatment approach for targeting pathologic lymphocyte trafficking to skin and indicate that 4-F-GlcNAc may be a promising agent for treatment of dermal tropism associated with malignancies and inflammatory disorders." 02/01/2012 - "4-F-GlcNAc enhanced tumor lymphocytic infiltration and promoted elevations in tumor-specific cytotoxic T cells and IFN-γ levels, while lowering IL-10 production. "
3.	Lymphoma (Lymphomas) 09/01/2006 - "These results indicate that 4-F-GlcNAc treatment can selectively downregulate the P-selectin ligand activity and potentially prevent dermal dissemination of cutaneous lymphomas."
4.	Inflammation (Inflammations) 12/15/2007 - "These T cell receptors, or E- and P-selectin ligands, can be targeted by the metabolic fluorosugar inhibitor, 4-F-GlcNAc, to blunt cutaneous inflammation. "
5.	Contact Dermatitis (Eczema, Contact) 10/01/2003 - "To analyze 4-F-GlcNAc efficacy in dampening effector T cell migration to inflamed skin, we elicited allergic contact hypersensitivity (CHS) reactions in mice treated with 4-F-GlcNAc. "

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2.	Polystyrenes (Polystyrene)
3.	Glucosamine (Dona)
4.	Antibodies
5.	A 121
6.	P-Selectin
7.	Ligands
8.	Interleukin-10 (Interleukin 10)
9.	T-Cell Antigen Receptors (T-Cell Receptor)