gadolinium(III)-tetraphenylporphine sulfonate
used as a contrast agent for in vivo magnetic resonance imaging of rat brain glioma
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Bio-Agent Context: Research Results
Related Diseases
1. | Neoplasms (Cancer)
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2. | Glioma (Gliomas)
05/01/1994
- " The tumor-selective accumulation of paramagnetic Gd-TPPS in glioma shortened T1 by 53%, from 1,315 msec +/- 199 to 628 msec +/- 106, and T2 by 34%, from 86 msec +/- 4 to 57 msec +/- 5 (2 days after injection of 0.25 mmol/kg Gd-TPPS). " 05/01/1994
- " Owing to the strong effect of Gd-TPPS on the T2 of glioma, normal brain tissue, tumor, and peritumorous edema could be distinguished on T2-weighted images alone." 05/01/1994
- " The synthetic metalloporphyrin gadolinium (III)-tetraphenylporphine sulfonate (TPPS) was successfully used as a contrast agent for in vivo magnetic resonance (MR) imaging of rat brain glioma. " 05/01/1994
- " In contrast to other contrast agents studied (Gd-DTPA, manganese [III]-TPPS), Gd-TPPS produced hypointensity in glioma on T2-weighted images. " 05/01/1994
- " After injection of Gd-TPPS, the signal intensity of experimental rat brain glioma distinctly increased on T1-weighted MR images, an effect similar to that produced by the clinically applied MR imaging contrast agent gadolinium diethylenetriaminepentaacetic acid (DTPA). "
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3. | Edema (Dropsy)
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4. | Brain Neoplasms (Brain Tumor)
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