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B 464 (B464)

a synthetic lipopolysaccharide antagonist

Also Known As:

B464; B-464

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Acute Lung Injury 10/01/1996 - "These in vivo data, together with in vitro evidence of suppressed cellular responses, suggest that B464 (1) inhibits neutrophil accumulation in lung tissue, and (2) attenuates the development of acute lung injury by blocking the activation of neutrophils and mononuclear cells as well as the interaction between neutrophils and endothelial cells." 10/01/1996 - "We then studied the effects of B464 pretreatment on acute lung injury elicited by intravenous LPS administration in vivo. " 10/01/1996 - "We investigated the effects of B464 on both LPS-induced cellular responses in vitro and acute lung injury in vivo. " 10/01/1996 - "Protective effect of B464, a lipid A analog, on endotoxin-induced cellular responses and acute lung injury."
2.	Lung Injury 10/01/1996 - "In the LPS + B464 group, no changes were observed in either plasma TNF-alpha or lung injury parameters. "
3.	Neutropenia 10/01/1996 - "Transient peripheral neutropenia and subsequent rapid recovery (p > 0.05, p < 0.001, p < 0.01, and p > 0.05 at 15 min and 1, 2, and 4 h, respectively) were observed in the LPS + B464 group. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Lipid A
3.	Endotoxins