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tamsulosin (Flomax)

an alpha 1 adrenoreceptor blocker; RN refers to (R)-isomer; approved for treatment of benign prostatic hyperplasia; floppy iris syndrome during cataract surgery has been noted

Also Known As:

Flomax; 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; Abbott laboratories brand of tamsulosin hydrochloride; tamsulosin hydrochloride; 5-((2R)-2-(2-(2-ethoxyphenoxy)ethylamino)propyl)-2-methoxy-benzenesulfonamide

Networked: 619 relevant articles (130 outcomes, 179 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amides: 231
  - Sulfonamides: 931
    - tamsulosin: 619
- Sulfur Compounds: 135
  - Sulfones: 136
    - Sulfonamides: 931
      - tamsulosin: 619

Experts

1.	Kaplan, Steven A: 22 articles (11/2015 - 11/2006)
2.	Roehrborn, Claus G: 15 articles (09/2015 - 11/2006)
3.	Montorsi, Francesco: 9 articles (04/2014 - 02/2008)
4.	Barkin, Jack: 8 articles (04/2014 - 11/2007)
5.	Oelke, Matthias: 7 articles (01/2016 - 05/2012)
6.	Masumori, Naoya: 7 articles (03/2015 - 11/2005)
7.	Wilson, Timothy H: 7 articles (10/2014 - 02/2011)
8.	Tsukamoto, Taiji: 6 articles (03/2015 - 11/2005)
9.	Muzzonigro, Giovanni: 6 articles (01/2015 - 12/2003)
10.	Gotoh, Momokazu: 6 articles (10/2013 - 09/2005)

Related Diseases

1.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/01/2013 - "Tamsulosin hydrochloride is one of the most potent drugs for treatment of benign prostatic hyperplasia (BPH), however, the efficacy of tamsulosin hydrochloride varies among individuals. " 07/01/2013 - "Tamsulosin HCl capsules showed a significant statistical improvement in the erectile function, sexual desire, and intercourse satisfaction score with significant improvement in total IIEF in patients with lower urinary tract symptoms because of benign prostatic hyperplasia." 11/01/2012 - "Combination therapy significantly increased the time to benign prostatic hyperplasia clinical progression and resulted in improved International Prostate Symptom Score, maximum urinary flow rate, quality of life, and reduced prostate volume in Asian and Caucasian men who received combination therapy compared with tamsulosin monotherapy. " 06/24/2009 - "Tamsulosin (0.3-300 microg/kg) also dose-dependently inhibited the intraurethral pressure increase in both groups, but it had a hypotensive effect that was significantly greater in old than in young dogs with benign prostatic hyperplasia. " 11/01/1998 - "Tamsulosin was safe and effective, and clinically and statistically superior to placebo in relieving symptoms of benign prostatic hyperplasia in men with moderate to severe symptoms at baseline. "
2.	Shock 11/01/2005 - "To evaluate whether tamsulosin, as an alpha(1)-blocker, was effective for the treatment of steinstrasse in the lower ureter after shock wave lithotripsy. " 08/01/2013 - "The objective of this study was to evaluate the efficacy of tamsulosin on stone clearance after extracorporeal shock wave lithotripsy (ESWL) in patients with a single proximal ureteral stone. " 03/01/2008 - "Several randomized trials published recently have demonstrated the role of tamsulosin in helping the clearance of ureteric fragments after shock wave lithotripsy. " 08/01/2013 - "A prospective randomized controlled trial of the efficacy of tamsulosin after extracorporeal shock wave lithotripsy for a single proximal ureteral stone." 11/01/2011 - "To determine the efficacy of the tamsulosin oral controlled absorption system as an adjuvant therapy to extracorporeal shock wave lithotripsy (ESWL) for the expulsion of ureteral and renal stones. "
3.	Pain (Aches) 04/05/2009 - "Tamsulosin, an alpha-1 receptor antagonist, has been demonstrated effective in promoting distal ureteral stone passage and in reducing pain associated with stone expulsion. " 12/01/2015 - "This study reveals no difference in the proportion of stone passage or high pain score and pain medication utilization at 7 days between tamsulosin and placebo." 12/01/2015 - "The objective of the study is to determine if tamsulosin initiated in the emergency department (ED) decreases the time to ureteral stone passage at 1 week or time to pain resolution, compared to placebo. " 01/01/2014 - "In this study, although the addition of tamsulosin to conservative treatment of distal ureteral stones in the distal ureteral stone expulsion showed no significant difference between the two groups, but the reduction in the duration of expulsion, reduce pain and reduce the need for analgesic has been beneficial." 11/01/2010 - "Patients in group 1 (study group) received a single daily morning dose of tamsulosin (0.4 mg) for a maximum of 4 weeks, in addition to pain-relieving therapy. "
4.	Overactive Urinary Bladder (Overactive Bladder) 03/01/2015 - "Combined tamsulosin and mirabegron treatment is effective and safe for patients with benign prostatic obstruction who have overactive bladder symptoms after tamsulosin monotherapy." 08/01/2015 - "Re: A Randomized Controlled Study of the Efficacy of Tamsulosin Monotherapy and its Combination with Mirabegron for Overactive Bladder Induced by Benign Prostatic Obstruction: K. " 03/01/2015 - "A randomized controlled study of the efficacy of tamsulosin monotherapy and its combination with mirabegron for overactive bladder induced by benign prostatic obstruction." 03/01/2015 - "Percentage of patients with relative prevalence of symptoms of overactive bladder slightly increases against administration of Tamsulosin and reaches initial values at the time of administration of anti-muscarinic drugs with absolute decrease in number of such patients. " 03/01/2015 - "We evaluated the efficacy and safety of add-on treatment with a β3-adrenoceptor agonist (mirabegron) for overactive bladder symptoms remaining after α1-blocker (tamsulosin) treatment in men with benign prostatic obstruction. "
5.	Nocturia 05/01/2014 - "The α1-adrenoceptor antagonist tamsulosin significantly improved nocturia and sleep quality as well as LUTS in women with low Qmax." 05/01/2014 - "We assessed the effects of the α1-adrenoceptor antagonist, tamsulosin, on nocturia and quality of sleep, for the treatment of lower urinary tract symptoms (LUTS) in women with a maximal flow rate (Qmax) less than 15 mL/sec. From January 2008 to December 2009, women with LUTS [Qmax ≤ 15 mL/s, International Prostate Symptom Score (IPSS) ≥ 8] and nocturia (void/night ≥ 1) were selected for this study. " 11/01/2008 - "The primary purpose of this study was the improvement of nocturia in patients with a poor response to tamsulosin. " 10/01/2014 - "Reduction in nocturia score with combination therapy was significantly (p ≤ 0.01) better than tamsulosin monotherapy across all baseline subgroups tested, except for men with previous 5ARI use. " 05/01/2014 - "The α1 adrenoceptor antagonist tamsulosin for the treatment of voiding symptoms improves nocturia and sleep quality in women."

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Related Therapies and Procedures

1.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
2.	Catheters
3.	Stents
4.	Transurethral Resection of Prostate (TURP)
5.	Brachytherapy