B 581

blocks farnesylated but not geranylgeranylated or myristylated, oncogenic Ras signaling & transformation

Also Known As:

B-581; B581

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Tanguay, R M: 1 article (08/2001)
2.	Jorquera, R: 1 article (08/2001)

1.	Chromosomal Instability (Chromosome Stability) 08/15/2001 - "Pre-treatment with the MEK inhibitor PD98059 and the Ras farnesylation inhibitor B581 decreased the formation of CREST-positive micronuclei by approximately 75%, confirming the partial contribution of the Ras/ERK effector pathway to the induction of chromosomal instability by FAA. "

1.	PD 98059