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cryptophycin

a potent antitumor cyclic depsipeptide active against drug-resistant cells; from cyanobacteria (blue-green algae) of the genus Nostoc; structure given in first source;

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - cryptophycin: 16
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - Depsipeptides: 297
      - cryptophycin: 16

Experts

1.	Figueras, Eduard: 4 articles (05/2019 - 07/2017)
2.	Sewald, Norbert: 4 articles (05/2019 - 07/2017)
3.	Borbély, Adina: 3 articles (05/2019 - 11/2018)
4.	Steinkühler, Christian: 3 articles (05/2019 - 11/2018)
5.	Cazzamalli, Samuele: 2 articles (12/2018 - 11/2018)
6.	Neri, Dario: 2 articles (12/2018 - 11/2018)
7.	Pethő, Lilla: 2 articles (12/2018 - 11/2018)
8.	Auciello, Giulio: 1 article (05/2019)
9.	Cordella, Paola: 1 article (05/2019)
10.	Esposito, Simone: 1 article (05/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2005 - "Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors." 01/01/2019 - "Higher cryptophycin metabolite levels were measured in NRP1-expressing tumors, evidence of NRP1-mediated enhanced drug uptake and presumably responsible for the superior antitumor efficacy. " 06/01/2005 - "After the examination of 81 different Cryptophycin analogs in tumor bearing animals, C-309 has emerged as superior to all others. " 11/01/2002 - "Cryptophycin (CP)-52, a synthetic analog of CP-1, possesses potent and selective antiproliferative activity against human solid tumors both and. " 07/15/1994 - "This property may confer an advantage to cryptophycin in the chemotherapy of drug-resistant tumors."
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2006 - "A multicenter phase II study of the cryptophycin analog LY355703 in patients with platinum-resistant ovarian cancer."
3.	Renal Cell Carcinoma (Grawitz Tumor) 12/31/2018 - "Erratum: In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinoma." 11/30/2018 - "In Vivo Antitumor Activity of a Novel Acetazolamide-Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas."
4.	Vulvar Vestibulitis 06/01/2000 - "Acute vulvar vestibulitis occurring during chemotherapy with cryptophycin analogue LY355703."
5.	Prostatic Neoplasms (Prostate Cancer) 12/01/2002 - "Cryptophycin 52-induced apoptosis in prostate cancer cells is therefore associated with multiple cell line-specific alterations in apoptosis-associated proteins and pathways."

Related Drugs and Biologics

1.	cryptophycin 52 (cryptophycin-52)
2.	Platinum
3.	Antineoplastic Agents (Antineoplastics)
4.	Acetazolamide (Diamox)
5.	Depsipeptides
6.	Member 1 Subfamily B ATP Binding Cassette Transporter
7.	Paclitaxel (Taxol)
8.	Vinblastine (Vinblastine Sulfate)
9.	Proteins (Proteins, Gene)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics