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phenylalanylproline
Also Known As:
D-Phe-Pro; L-Phe-Pro
Networked:
7
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
Dipeptides: 945
phenylalanylproline: 7
Experts
1.
Brass, Lawrence F
: 1 article (10/2020)
2.
DeCortin, Michael E
: 1 article (10/2020)
3.
Diamond, Scott L
: 1 article (10/2020)
Related Diseases
1.
Seizures (Absence Seizure)
01/01/1992 - "
dTyr-D-Phe3 (Pro-D-Phe-Pro-Gly) interacts specifically with amygdaloid-kindled seizures and is capable of preventing the learning deficit occurring after kindling.
"
01/01/1991 - "
The beta-casomorphin derivative Pro-D-Phe-Pro-Gly was effective against electrically induced seizures.
"
01/01/1991 - "
Additionally, we tested the influence of orally administered Pro-Phe-D-Pro-Gly on pentylenetetrazol-induced seizures and Pro-D-Phe-Pro-Gly on electrically induced seizures.
"
2.
Thrombosis (Thrombus)
10/01/2020 - "
Thrombin inhibition (with D-Phe-Pro-Arg-CMK) reduced the number of P-selectin-positive platelets and lowered thrombus stability through the reduction of P-selectin-positive platelets.
"
10/01/1992 - "
Since thrombin plays an important role in platelet-mediated arterial thrombosis, we have examined the antiplatelet activity of a synthetic thrombin inhibitor, DuP 714 (Ac-(D)Phe-Pro-boroArg), in comparison with that of the naturally occurring inhibitor hirudin.
"
03/01/1998 - "
We modified a previously reported rat arterial thrombosis model to allow simultaneous assessment of the arterial and venous antithrombotic efficacies of heparin, hirudin, hirulog, a novel thrombin inhibitor H-(N-Me-D-Phe)-Pro-L-trans-4-aminocyclohexyl-Gly-[CO-CO]-NHCH3+ ++ (L-370,518) and the factor Xa inhibitor tick anticoagulant peptide in rabbits.
"
3.
Wounds and Injuries (Trauma)
09/01/1997 - "
The authors then developed a new type of wound dressing (AGX), a drug delivery system in which gentamicin is bound to polyvinylalcohol hydrogel through an enzymatically degradable peptide linker containing a -(D)-Phe-Pro-Arg-sequence.
"
4.
Autolysis
12/15/1997 - "
The protease active site was inhibited with D-Phe-Pro-Arg-chloromethylketone (PPACK) to reduce autolysis.
"
Related Drugs and Biologics
1.
beta-casomorphins
2.
Thrombin
3.
Hirudins
4.
Factor Xa Inhibitors
5.
Hydrogels
6.
P-Selectin
7.
Peptides (Polypeptides)
8.
Peptide Hydrolases (Proteases)
9.
Pentylenetetrazole (Metrazol)
10.
Heparin (Liquaemin)