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SUN 8399

a serotonergic 5-HT1A-receptor agonist

Also Known As:

4-(4-(4-(2-pyrimidinyl)piperazin-1-yl)butyl)-2,3,4,5-tetrahydro-1,4-benzoxazepine-3,5-dione; SUN-8399; SUN8399

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azepines: 11
    - Oxazepines: 5
      - SUN 8399: 1

Related Diseases

1.	Vomiting 02/01/1994 - "Pretreatment with 8-OH-DPAT or SUN8399 dose-dependently inhibited emesis elicited by nicotine (4.0 mg/kg, s.c.), veratrine (0.7 mg/kg, s.c.), cisplatin (20 mg/kg, i.p.) and copper sulfate (40 mg/kg, p.o.). "
2.	Motion Sickness (Airsickness) 02/01/1994 - "The antiemetic effects of six serotonergic 5-HT1A-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-OH-DPAT), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus. "

Related Drugs and Biologics

1.	Copper Sulfate (Sulfate, Copper)
2.	8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
3.	Veratrine
4.	Nicotine
5.	Cisplatin (Platino)
6.	Buspirone (Buspar)
7.	Antiemetics
8.	tandospirone
9.	ipsapirone
10.	gepirone