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zinc bis(histidinate)

RN given refers to (N,O)-isomer

Also Known As:

Zn(His)2; Zn-His(2); zinc bis(histidinate), (65)Zn-labeled, N,O-isomer; zinc bis(histidinate), N,N(3)-isomer; zinc-bis-histidinate

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Essential Amino Acids: 1152
    - Histidine: 2980
      - zinc bis(histidinate): 4
  - Cyclic Amino Acids: 3
    - Histidine: 2980
      - zinc bis(histidinate): 4
Organic Chemicals: 133
- Organometallic Compounds: 64
  - zinc bis(histidinate): 4

Experts

1.	Chivers, Peter T: 1 article (08/2010)
2.	Herbst, Robert W: 1 article (08/2010)
3.	Maroney, Michael J: 1 article (08/2010)
4.	Martin-Diaconescu, Vlad: 1 article (08/2010)
5.	O'Brien, Kerrie: 1 article (08/2010)
6.	Perovic, Iva: 1 article (08/2010)
7.	Pochapsky, Susan Sondej: 1 article (08/2010)
8.	Pochapsky, Thomas C: 1 article (08/2010)

Related Diseases

1.	Ischemia 06/01/1994 - "Hearts, perfused with Krebs-Henseleit buffer with or without zinc-bis-histidinate, were subjected to 20 min of "no-flow" normothermic global ischemia. " 07/01/1997 - "Domestic pigs (35 to 50 kg) on left-sided cardiopulmonary bypass were subjected to 90 minutes of regional ischemia followed by 60 minutes of hypothermic cardioplegic arrest induced by antegrade infusion of 20 mL/kg cold St. Thomas' #2 cardioplegic solution with or without 100 mumol/L of zinc-bis-histidinate and maintained by infusion of 10 mL/kg of the same every 20 minutes. " 01/01/1999 - "Isolated rat hearts were subjected to 20 min of normothermic global ischemia, followed by 30 min of reperfusion; after 20 min of preischemic loading with Krebs-Henseleit buffer +/- 20 or 30 microM zinc-bis-histidinate (Zn-His2), 0.5 mM deferoxamine (DEF) or 42 microM neocuproine (NEO). "
2.	Shock 08/04/2010 - "At pH 6.3, an internal pH that occurs during acid shock, the zinc site undergoes unprecedented ligand substitutions to convert from a Zn(Cys)(4) site to a Zn(His)(2)(Cys)(2) site. "

Related Drugs and Biologics

1.	Krebs-Henseleit solution
2.	Zinc
3.	Ligands
4.	Deferoxamine (Desferal)
5.	Cardioplegic Solutions
6.	Acids
7.	butyl phosphorotrithioate (DEF)
8.	neocuproine

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)