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5-(2-bromovinyl)-2'-deoxy-4'-thiouridine

structure given in first source; RN refers to (E)-isomer

Also Known As:

(E)-5-(2-bromovinyl)-2'-deoxy-4'-thiouridine; S-BVDU

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Uridine: 1186
        Deoxyuridine: 331
        Bromodeoxyuridine: 3535
        5-(2-bromovinyl)-2'-deoxy-4'-thiouridine: 2
        Thiouridine: 12
        5-(2-bromovinyl)-2'-deoxy-4'-thiouridine: 2
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thionucleosides: 2
    - Thiouridine: 12
      - 5-(2-bromovinyl)-2'-deoxy-4'-thiouridine: 2

Related Diseases

1.

Neoplasms (Cancer)

06/01/1994 - "From this study, (E)-5-(2-bromovinyl)-2'-deoxy-4'-thiouridine emerged as a promising candidate compound for the treatment of HSV-1 TK gene-transfected tumors in vivo, due to its metabolic stability (i.e., resistance to hydrolysis by thymidine phosphorylase)."
10/01/1997 - "In addition, the intrinsic resistance of BVaraU, IVFAU and S-BVDU to glycosidic bond cleavage by mammalian dThd phosphorylases makes them promising candidate compounds for the treatment of VZVtk gene-transfected tumors in vivo."

Related Drugs and Biologics

1.	Thymidine Phosphorylase
2.	Phosphorylases (Glucan Phosphorylase)