nardilysin

catalyzes cleavage at the N-terminus of arginine residues in dibasic stretches of proteins; located in brain cortex; amino acid sequence in first source; GenBank L27124; GenBank U64898 (human)

Also Known As:

Networked: 34 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Nishi, Eiichiro: 15 articles (01/2021 - 07/2002)
2.	Ohno, Mikiko: 11 articles (01/2021 - 05/2012)
3.	Kimura, Takeshi: 10 articles (01/2020 - 05/2012)
4.	Nishi, Kiyoto: 9 articles (01/2021 - 01/2014)
5.	Chiba, Tsutomu: 5 articles (01/2019 - 05/2012)
6.	Seno, Hiroshi: 5 articles (01/2019 - 05/2012)
7.	Reiser, Georg: 5 articles (03/2014 - 03/2009)
8.	Stricker, Rolf: 5 articles (03/2014 - 03/2009)
9.	Hiraoka, Yoshinori: 4 articles (01/2021 - 05/2012)
10.	Ikuta, Kozo: 4 articles (01/2019 - 01/2014)

Related Diseases

1.	Extramammary Paget Disease (Paget Disease, Extramammary) 09/01/2023 - "Immunohistochemical and clinicopathological study regarding nardilysin on extramammary Paget's disease."
2.	Cerebral Infarction 07/01/2019 - "Serum nardilysin concentrations were quantified at malignant cerebral infarction diagnosis moment in 105 patients and at study entrance in 105 healthy controls. " 07/01/2019 - "Here, we intended to investigate the relationship between serum nardilysin levels and prognosis of patients with malignant cerebral infarction. " 07/01/2019 - "Clinical determination of serum nardilysin levels in predicting 30-day mortality among adults with malignant cerebral infarction." 07/01/2019 - "Rising serum nardilysin concentrations following malignant cerebral infarction are strongly related to stroke severity, inflammatory extent and a higher risk of mortality, substantializing serum nardilysin as a potential prognostic biomarker for malignant cerebral infarction."
3.	Neoplasms (Cancer) 01/01/2014 - "These results suggest that nardilysin is involved in tumor progression, and is an independent prognostic classifier in patients with ESCC." 01/01/2014 - "Nardilysin-positive ESCC cases were more advanced in terms of T classification (P = 0.0007), N classification (P = 0.0164), and tumor stage (P < 0.0001) than nardilysin-negative ESCC cases. " 01/01/2011 - "By broadening the antigenic peptide repertoire, nardilysin and TOP strengthen the immune defense against intracellular pathogens and cancer." 01/01/2017 - "Nardilysin regulates inflammation, metaplasia, and tumors in murine stomach." 01/01/2019 - "Nardilysin (NRDC), a metalloendopeptidase of the M16 family, has been suggested to play important roles in inflammation and several cancer types. "
4.	Acute Coronary Syndrome 01/01/2019 - "Response to Letter of Stephenson et al.: Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome." 01/01/2019 - "Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome." 01/01/2018 - "Nardilysin: A potential biomarker for the early diagnosis of acute coronary syndrome." 01/01/2018 - "Reply: Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome." 09/15/2017 - "Nardilysin is a promising biomarker for the early diagnosis of acute coronary syndrome."
5.	Alzheimer Disease (Alzheimer's Disease) 03/01/2014 - "Nardilysin, ADAM10, and Alzheimer's disease: of mice and men." 03/01/2009 - "Recent reports point to an involvement of nardilysin in the pathophysiology of Alzheimer's disease. " 01/01/2014 - "Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model." 03/01/2009 - "Compared to controls, in Alzheimer's disease and in Down syndrome brains there is a decreased cellular expression of all three antigens, and a reduction in the number of those neurons that co-express nardilysin with ADAM10 or with ADAM17. " 03/01/2009 - "We immunolocalised nardilysin, ADAM10, and ADAM17 in cortical regions of normal aged brain, in Alzheimer's disease, and in Down syndrome brains and counted the number of protease-expressing neurons. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Proteins (Proteins, Gene)
3.	Metalloendopeptidases (Metalloendopeptidase)
4.	nardilysin
5.	Peptide Hydrolases (Proteases)
6.	Heparin-binding EGF-like Growth Factor (HB-EGF)
7.	Amyloid Precursor Protein Secretases (beta-Secretase)
8.	Metalloproteases (Metalloproteinases)
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Cytokines