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U 76074

a carzelesin metabolite; structure given in first source

Also Known As:

U-76,074; U-76074

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Duocarmycins: 63
        U 76074: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Duocarmycins: 63
        U 76074: 2
    - Benzofurans: 26
      - U 76074: 2

Related Diseases

1.	Neutropenia 03/01/1999 - "There was no relationship between neutropenia and the AUC of the prodrug Carzelesin, but the presence of detectable plasma levels of the active metabolite U-76,074 was usually associated with a substantial decrease in ANC values."
2.	Leukemia L1210 09/15/1992 - "Although carzelesin was less potent in terms of in vitro cytotoxicity and in vivo optimal dosage and showed low affinity for binding to DNA, it was therapeutically more efficacious against mouse L1210 leukemia than was U-76074 or adozelesin (U-73975), another cyclopropylpyrroloindole analogue which is currently in phase I clinical trials. "
3.	Adenocarcinoma 09/15/1992 - "Carzelesin also proved to be more efficacious than U-76074 or adozelesin against mouse pancreatic ductal 02 adenocarcinoma, a system reported to be resistant to every agent tested. "

Related Drugs and Biologics

1.	carzelesin
2.	Prodrugs
3.	DNA (Deoxyribonucleic Acid)
4.	adozelesin