reteplase

04/01/2015 - "To assess the safety and efficacy of intravenous Retelex (Reteplase) injection in management of patients with ST elevated myocardial infarction in clinical practice. "
10/01/2015 - "This study was aimed to examine the reteplase pattern of ADR and its associated risk factors in patients with acute ST-elevation myocardial infarction. "
03/01/2019 - "This cross-sectional study was conducted on the patients referring to the emergency department in Tabriz, Iran who were diagnosed with STEMI and began receiving treatment with reteplase. "
04/01/2015 - "Reteplase is commonly used in the management of ST elevated myocardial infarction. "
01/01/2007 - "With its efficacy, and the ease of administration of the bolus doses potentially minimizing dosage errors when treatment is administered under time pressure, reteplase is a valuable option for pre- or in-hospital thrombolytic treatment in patients with STEMI, and is a useful thrombolytic for the treatment of the other thrombotic occlusive disorders described."

10/01/2007 - "Reteplase may prove safe and effective as a provocative agent, stimulating bleeding to allow localization, in patients with occult, recurrent, massive LGIB."
04/01/2023 - "However, reteplase has a narrow therapeutic window and serious side effects, such as an increased risk of bleeding."
04/01/2023 - "Reteplase increases your risk for bleeding, which can be severe or life-threatening. "
10/01/1996 - "As with other thrombolytics, bleeding was the most common adverse event seen in reteplase recipients. "
12/01/1996 - "All three studies demonstrated that reteplase therapy was not associated with an increase in bleeding complications or other adverse clinical events. "

02/01/2004 - "Clot lysis in a primate model of peripheral arterial occlusive disease with use of systemic or intraarterial reteplase: addition of abciximab results in improved vessel reperfusion."
03/01/2004 - "The safety and efficacy of increasing doses of intraarterial reteplase monotherapy and reteplase/abciximab combination therapy were examined in patients with acute peripheral arterial occlusive disease (PAOD). "
03/01/2004 - "Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: results from the RELAX trial."
01/01/2002 - "Initial experience with the combination of reteplase and abciximab for thrombolytic therapy in peripheral arterial occlusive disease: a pilot study."
02/01/2004 - "This study was designed to compare the ability of reteplase (a fibrinolytic agent) alone or in combination with abciximab (a monoclonal antibody antagonist of platelet glycoprotein IIb/IIIa) to achieve and sustain vessel patency in an acute model of peripheral arterial occlusive disease in cynomolgus monkeys. "

10/01/2019 - "Reteplase is highly efficacious in massive pulmonary embolism and results in rapid clinical improvement. "
04/24/2017 - "Conclusion: Treatment of intermediate-risk acute pulmonary embolism with reteplase is effective and safe and there are no obvious side effects. "
11/01/2019 - "In this study, we analyzed the efficacy and safety of reteplase in acute pulmonary embolism (PE). "
11/01/2019 - "Thrombolysis with reteplase in acute pulmonary embolism."
10/01/2019 - "Use of reteplase for thrombolysis in patients with massive pulmonary embolism diagnosed by bedside transthoracic echocardiography: A retrospective study of safety and efficacy."

07/01/2023 - "The decreased interaction between two chimeric reteplase and ATD of NR1 subunit in NMDAR which leads to lower neurotoxicity related to these drugs, can be the start of a way to conduct more tests and if the results confirm this feature, they can be considered potential drugs in acute ischemic stroke treatment."
01/01/2017 - "Administration of intravenous reteplase might be a choice of treatment of acute ischemic stroke."
01/01/2017 - "Providing full recovery with single-dose intravenous reteplase in a patient presented to emergency department with acute ischemic stroke."
07/01/2008 - "Intraarterial thrombolysis with reteplase in acute ischaemic stroke in a Pakistani center."
02/01/2004 - "Patients treated for acute ischemic stroke at our center between September 2000 and May 2002 received a maximum total dose of 4 U of reteplase intra-arterially in 1-U increments via superselective catheterization. "