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AG 331
structure given in second source
Also Known As:
AG-331; N(6)-(4-(N-morpholinosulfonyl)benzyl)-N(6)-methyl-2,6-diaminobenz(cd)indole glucuronate
Networked:
3
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
AG 331: 3
Related Diseases
1.
Neoplasms (Cancer)
04/21/1995 - "
Intra-day coefficient of variation was less than 9.5%, and inter-day coefficient of variation was less than 14.3% for an AG-331 concentration of 44 ng/ml. This method has been used to characterize the pharmacokinetics of AG-331 in cancer patients as part of ongoing Phase I trials.
"
04/21/1995 - "
High-performance liquid chromatographic method for the determination of AG-331, a novel anti-cancer agent, in human serum and urine using solid-phase extraction and photodiode-array detection.
"
01/01/1999 - "
Phase I study of AG 331, a novel thymidylate synthase inhibitor, in patients with refractory solid tumors.
"
2.
Hepatocellular Carcinoma (Hepatoma)
01/01/1994 - "
Similar results were also obtained in protection experiments with a human hepatoma cell line, HEPG2, although previous results obtained in colon- and breast-cancer cell lines have suggested TS specific effects for AG-331.
"
01/01/1994 - "
There was no evidence for any intracellular effect of AG-331 on dihydrofolate reductase (DHFR); however, the low degree of cross-resistance found for the H35FF line, which has elevated TS levels, suggested that TS may not be the sole locus of action of AG-331 in hepatoma cells.
"
3.
Breast Neoplasms (Breast Cancer)
01/01/1994 - "
Similar results were also obtained in protection experiments with a human hepatoma cell line, HEPG2, although previous results obtained in colon- and breast-cancer cell lines have suggested TS specific effects for AG-331.
"
Related Drugs and Biologics
1.
Thymidylate Synthase
2.
Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)