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2- carbomethoxy- 8- (3- fluoropropyl)- 3- (4- iodophenyl)tropane

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used in PET and SPECT imaging of dopamine transporters; structure in first source

Also Known As:

(18F)FP-CIT; (O-methyl-11C)beta-CIT-FP; 123I-FP-CIT; FP-CIT; FPCIT; I(123)-N-fluoropropyl-2-beta-carbomethoxy-3-(4-iodophenyl)nortropane; I(123)-N-omega-fluoropropyl-2-beta-carbomethoxy-3-beta(4-iodophenyl)nortropane; N-omega-fluoropropyl-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; beta-CIT-FP; fluoropropylcarbomethoxyiodophenylnortropane

Networked: 217 relevant articles (6 outcomes, 55 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Booij, Jan: 8 articles (12/2013 - 09/2002)
2.	Booij, J: 7 articles (03/2008 - 05/2000)
3.	Walker, Zuzana: 6 articles (02/2015 - 04/2007)
4.	Pappatà, Sabina: 6 articles (11/2014 - 03/2004)
5.	McKeith, Ian G: 6 articles (01/2009 - 06/2004)
6.	O'Brien, John T: 6 articles (01/2009 - 06/2004)
7.	Tinazzi, Michele: 5 articles (12/2015 - 10/2008)
8.	Barone, Paolo: 5 articles (11/2014 - 03/2004)
9.	Pellecchia, Maria Teresa: 5 articles (11/2014 - 03/2004)
10.	Grosset, Donald G: 5 articles (07/2012 - 09/2003)

Related Diseases

1.	Dementia (Dementias) 06/01/2007 - "To assess the utility of the appearances of occipital lobe perfusion on HMPAO SPECT in the diagnosis of dementia with Lewy bodies (DLB) using the 123I-FP-CIT findings as the diagnostic 'gold standard'. " 12/15/2015 - "We searched MEDLINE, CENTRAL and ClinicalTrials.gov to identify studies reporting enough data to determine accuracy measure of 123I-FP-CIT SPECT in differentiating between DLB and other dementia syndromes. " 03/01/2012 - "A systematic meta-analysis of published studies on the diagnostic accuracy of presynaptic dopaminergic imaging with ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies (DLB). " 03/01/2012 - "Diagnostic accuracy of ¹²³I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies." 12/15/2015 - "123I-FP-CIT SPECT can represent an accurate method to differentiate between DLB and other dementia syndromes. "
2.	Parkinson Disease (Parkinson's Disease) 06/01/2013 - "The aim of this study was to evaluate the feasibility of FP-CIT PET template-based quantitative analysis on F-18 FP-CIT PET in patients with de novo Parkinson's disease (PD), compared with MR-based and manual methods. " 11/01/2012 - "Accuracy of subjective and objective handwriting assessment for differentiating Parkinson's disease from tremulous subjects without evidence of dopaminergic deficits (SWEDDs): an FP-CIT-validated study." 04/01/2012 - "Then, a sample of 49 Jewish Israeli Parkinson's disease (PD) patients with available neuroimaging ([(123)I]-FP-CIT-SPECT) data was analyzed, to study association of confirmed AIP SNPs with level of dopaminergic deficits in the putamen. " 12/01/2011 - "The purpose of this study was to investigate the diagnostic value of dual time point F-18 FP-CIT PET imaging in idiopathic Parkinson's disease (PD). " 04/01/2010 - "Differences in nigro-striatal impairment in clinical variants of early Parkinson's disease: evidence from a FP-CIT SPECT study."
3.	Parkinsonian Disorders (Parkinsonism) 06/01/2011 - "Improved visual [(123)I]FP-CIT SPECT interpretation for evaluation of parkinsonism by visual rating of parametric distribution volume ratio images." 07/01/2014 - "To assess a group of patients with parkinsonism using serial studies with FP-CIT, basically the initial false negative results. " 11/01/2013 - "The objective of the present study was to study whether non-fluent/agrammatic patients without parkinsonism at baseline present decreased striatal 123I-FP-CIT uptake. " 07/01/2012 - "Study 1 was a trial of [(123)I]FP-CIT SPECT in patients with early suspected parkinsonism that compared baseline scans to the consensus clinical diagnosis established 3 years later. " 10/15/2011 - "The comparison between the results of FP-CIT and clinical manifestations showed: 4 patients with parkinsonism (PK) and pathological study; 4 without PK and normal study; 1 with PK and normal study and 1 without PK and pathological study. "
4.	Movement Disorders (Movement Disorder) 01/01/2015 - "We analyzed 516 files of subjects with movement disorders who were consecutively examined using [(123)I]-FP-CIT scan and determined whether the use of imaging was appropriate and if it improved clinical diagnosis or care of the patient. " 01/01/2014 - "¹²³I-FP-CIT (DaTSCAN) SPECT studies of the nigrostriatal pathway are a valuable tool in the diagnosis of movement disorders. " 04/01/2013 - "Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT study: reply to comment by Erro et al." 04/01/2013 - "Comment on Di Giuda et al.: Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT SPECT study." 12/01/2012 - "Dopaminergic dysfunction and psychiatric symptoms in movement disorders: a 123I-FP-CIT SPECT study."
5.	Tremor (Tremors) 05/01/2000 - "Visual assessment of [123I]-FP-CIT SPECT images is an easily applied diagnostic test which is helpful in the differential diagnosis of tremor disorders and in confirming a clinical diagnosis of a hypokinetic-rigid syndrome." 01/01/2011 - "In a second part of the study, we retrospectively reviewed SPECT with FP-CIT data and confirmed the lack of correlation between dopaminergic loss and tremor by comparing DAT binding values of 82 PD subjects with bilateral tremor (n = 27), unilateral tremor (n = 22), and no tremor (n = 33). " 10/01/2014 - "The mean FP-CIT caudate nucleus uptake and the left caudate nucleus uptake were higher in PD patients with tremor than in PD patients without tremor (mean 9.0 % higher, left 10.5 % higher; p < 0.05), whereas there were no differences between tremor and non-tremor control patients. " 12/01/2013 - "The reduced [18F] FP-CIT uptake was significantly associated with earlier age-at-onset of tremor and asymmetric presentation of resting tremor. " 11/01/2011 - "123I-FP-CIT uptake was higher in the ipsilateral caudate (P=0.0050) and putamen (P=0.0012) of tremor type patients compared to akinetic-rigid type patients. "

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4.	ioflupane
5.	diazenedicarboxylic acid bis(N'-methylpiperazide)
6.	Antipsychotic Agents (Antipsychotics)
7.	Levodopa (L Dopa)
8.	Iodine
9.	Amiodarone (Amiodarona)
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