WIN 64821

a dimerized Trp-Phe condensate; structurally similar to verticillins and chaetocins; a nonpeptide neurokinin antagonist; structure given in first source; substance P antagonist

Also Known As:

WIN-64821; Chaetocin, 2,5:2',5'-dide(epidithio)-3,3'-didemethyl-19,19'-dideoxy-19,19'-diphenyl-, (2alpha,2'beta,5beta,5'alpha)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - WIN 64821: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - WIN 64821: 2

Experts

1.	Kato, Mitsuyasu: 1 article (01/2019)
2.	Oguri, Hiroki: 1 article (01/2019)
3.	Oikawa, Hideaki: 1 article (01/2019)
4.	Suzuki, Hiroyuki: 1 article (01/2019)
5.	Tsubouchi, Akira: 1 article (01/2019)
6.	Wada, Mitsuhiro: 1 article (01/2019)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/01/2019 - "Not only the stereochemical modifications of (+)-WIN 64821 at the 3-/3'-, 11-/11'-, and 15-/15'-positions, but also ring cleavage of the diketopiperazine moieties, allowed the generation of a lead compound exhibiting potent growth inhibitory activity (IC50 =3.03 μm) toward human colon cancer cells. "
2.	Astrocytoma (Pilocytic Astrocytoma) 04/01/1994 - "WIN 64821 was also evaluated in NK1 functional assays and was found to be a competitive antagonist of SP-induced contractility in the guinea pig ileum (pA2 = 6.6) as well as an inhibitor of SP-induced 45Ca2+ efflux from human astrocytoma U-373 MG cells (IC50 = 0.6 microM). "

Related Drugs and Biologics

1.	Diketopiperazines